Chen, Angela and Halilovic, Lida and Shay, Jia-Hong and Koch, Aline and Mitter, Neena and Jin, Hailing (2023) Improving RNA-based crop protection through nanotechnology and insights from cross-kingdom RNA trafficking. CURRENT OPINION IN PLANT BIOLOGY, 76: 102441. ISSN 1369-5266, 1879-0356
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Spray-induced gene silencing (SIGS) is a powerful and ecofriendly method for crop protection. Based off the discovery of RNA uptake ability in many fungal pathogens, the application of exogenous RNAs targeting pathogen/pest genes results in gene silencing and infection inhibition. However, SIGS remains hindered by the rapid degradation of RNA in the environment. As extracellular vesicles are used by plants, animals, and microbes in nature to transport RNAs for cross-kingdom/species RNA interference between hosts and microbes/pests, nanovesicles and other nanoparticles have been used to prevent RNA degradation. Efforts examining the effect of nanoparticles on RNA stability and internalization have identified key attributes that can inform better nanocarrier designs for SIGS. Understanding sRNA biogenesis, cross-kingdom/species RNAi, and how plants and pathogens/pests naturally interact are paramount for the design of SIGS strategies. Here, we focus on nanotechnology advancements for the engineering of innovative RNA-based disease control strategies against eukaryotic pathogens and pests.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTRACELLULAR VESICLES; INDUCED GENE; DSRNA; INTERFERENCE; HOST; RESISTANCE; DELIVERY; CARBON; WHEAT; NANOPARTICLES |
| Subjects: | 500 Science > 580 Botanical sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Lehrstuhl für Zellbiologie und Pflanzenphysiologie (Prof. Dr. Klaus Grasser) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2024 06:43 |
| Last Modified: | 24 Apr 2024 06:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60356 |
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