Charante, Frits van and Martinez-Perez, David and Guarch-Perez, Clara and Courtens, Charlotte and Sass, Andrea and Choinska, Emilia and Idaszek, Joanna and Calenbergh, Serge Van and Riool, Martijn and Zaat, Sebastian A. J. and Swieszkowski, Wojciech and Coenye, Tom (2023) 3D-printed wound dressings containing a fosmidomycin-derivative prevent <i>Acinetobacter</i> <i>baumannii</i> biofilm formation. ISCIENCE, 26 (9): 107557. ISSN , 2589-0042
Full text not available from this repository. (Request a copy)Abstract
Acinetobacter baumannii causes a wide range of infections, including wound infections. Multidrug-resistant A. baumannii is a major healthcare concern and the development of novel treatments against these infections is needed. Fosmidomycin is a repurposed antimalarial drug targeting the non-mevalonate pathway, and several derivatives show activity toward A. baumannii. We evaluated the antimicrobial activity of CC366, a fosmidomycin prodrug, against a collection of A. baumannii strains, using various in vitro and in vivo models; emphasis was placed on the evaluation of its anti-biofilm activity. We also developed a 3D-printed wound dressing containing CC366, using melt electrowriting technology. Minimal inhibitory concentrations of CC366 ranged from 1 to 64 mg/mL, and CC366 showed good biofilm inhibitory and moderate biofilm eradicating activity in vitro. CC366 successfully eluted from a 3D-printed dressing, the dressings prevented the formation of A. baumannnii wound biofilms in vitro and reduced A. baumannii infection in an in vivo mouse model.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STAPHYLOCOCCUS-AUREUS; ISOPRENOID BIOSYNTHESIS; ESCHERICHIA-COLI; RESISTANCE; PRODRUGS; STRAINS; ANTIMALARIAL; ANTIBIOTICS; INFECTIONS; BACTERIAL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 09:59 |
| Last Modified: | 30 Jan 2024 09:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60381 |
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