Berghoff, A. S. and Ilhan-Mutlu, A. and Dinhof, C. and Magerle, M. and Hackl, M. and Widhalm, G. and Hainfellner, J. A. and Dieckmann, K. and Pichler, J. and Hutterer, M. and Melchardt, T. and Bartsch, R. and Zielinski, C. C. and Birner, P. and Preusser, M. (2015) Differential role of angiogenesis and tumour cell proliferation in brain metastases according to primary tumour type: analysis of 639 cases. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 41 (2). E41-E55. ISSN 0305-1846, 1365-2990
Full text not available from this repository. (Request a copy)Abstract
AimWe aimed to characterize angiogenesis and proliferation and their correlation with clinical characteristics in a large brain metastasis (BM) series. MethodsKi67 proliferation index, microvascular density (MVD) and hypoxia-inducible factor 1 alpha (HIF-1 alpha) index were determined by immunohistochemistry in BM and primary tumour specimens. ResultsSix hundred thirty-nine BM specimens of 639 patients with lung cancer (344/639; 53.8%), breast cancer (105/639; 16.4%), melanoma (67/639; 10.5%), renal cell carcinoma (RCC; 52/639; 8.1%) or colorectal cancer (CRC; 71/639; 11.1%) were available. Specimens of the corresponding primary tumour were available in 113/639 (17.7%) cases. Median Ki67 index was highest in CRC BM and lowest in RCC BM (P<0.001). MVD and HIF-1 alpha index were both highest in RCC BM and lowest in melanoma BM (P<0.001). Significantly higher Ki67 indices, MVD and HIF-1 alpha indices in the BM than in matched primary tumours were observed for breast cancer, non-small cell lung cancer (NSCLC) and CRC. Correlation of tissue-based parameters with overall survival in individual tumour types showed a favourable and independent prognostic impact of low Ki67 index [hazard ratio (HR) 1.015; P<0.001] in NSCLC BM and of low Ki67 index (HR 1.027; P=0.008) and high angiogenic activity (HR 1.877; P=0.002) in RCC. ConclusionOur data argue for differential pathobiological and clinical relevance of Ki67 index, HIF1-alpha index and MVD between primary tumour types in BM patients. An independent prognostic impact of tissue-based characteristics was observed in patients with BM from NSCLC and RCC, supporting the incorporation of these tissue-based parameters into diagnosis-specific prognostic scores.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MICROVASCULAR DENSITY; INDEPENDENT PREDICTOR; HYPOXIA; KI67; PROGNOSIS; CARCINOMA; INDEX; OVEREXPRESSION; PROPHYLAXIS; EXPRESSION; brain metastases; HIF-1 alpha index; ki67 proliferation index; microvascular density |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jul 2019 07:25 |
| Last Modified: | 25 Jul 2019 07:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6039 |
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