Comparison of computed tomography (CT) and contrast-enhanced ultrasound (CEUS) for the quantitative evaluation of an ablation defect following radiofrequency ablation of malignant liver lesions

Bruenn, K. and Beyer, L. and Haimerl, M. and Pregler, B. and Stroszczynski, C. and Jung, E. M. and Wiggermann, P. (2017) Comparison of computed tomography (CT) and contrast-enhanced ultrasound (CEUS) for the quantitative evaluation of an ablation defect following radiofrequency ablation of malignant liver lesions. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 67 (3-4). pp. 445-451. ISSN 1386-0291, 1875-8622

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Abstract

OBJECTIVE: To compare contrast-enhanced computed tomography (CT) and contrast-enhanced ultrasound (CEUS) for the quantitative evaluation of an ablation defect following radiofrequency ablation of malignant liver lesions in a prospective study. MATERIALS AND METHODS: 22 radiofrequency ablations of malignant liver tumors were performed. The ablation defects were then measured and evaluated by two independent examiners via contrast-enhanced computed tomography (CT) and contrast-enhanced ultrasound (CEUS) using a 1-5MHz multifrequency convex ultrasound transducer (LOGIQ E9, GE) with respect to the short-axis diameter, the long-axis diameter, and the area. RESULTS: Quantitative evaluation of ablation defects is possible with both contrast-enhanced CT and CEUS. The average long-axis diameter was 47.1mm (+/- 11.08; +/- 23,5%) on CEUS and 56.48mm (+/- 14.14; +/- 25,0%) on CT; the short-axis diameterwas 39.72mm(+/- 11.14; +/- 28,05%) on CEUS and 40.27mm(+/- 10.50; +/- 26,07%) on CT; the areawas 1439.82 mm(2) (+/- 678.57; +/- 47,13%) on CEUS and 2392.68 mm(2) (1147.67; +/- 48,0%) on CT. On average, ablation defects are assessed to be larger on CT than on CEUS. A significant correlation between the modalities could not be achieved for all measurement axes. CONCLUSION: CEUS can be used for the postinterventional detection and evaluation of ablation defects. However, these are always assessed to be larger on contrast-enhanced CT than CEUS.

Item Type: Article
Uncontrolled Keywords: HEPATOCELLULAR-CARCINOMA; MICROWAVE ABLATION; THERMAL ABLATION; PORCINE MODEL; METASTASES; DIAGNOSIS; SONOGRAPHY; CANCER; PROBES; TUMORS; CEUS; CT; ablation; RFA; HCC
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Röntgendiagnostik
Depositing User: Dr. Gernot Deinzer
Date Deposited: 14 Dec 2018 13:01
Last Modified: 26 Apr 2019 12:16
URI: https://pred.uni-regensburg.de/id/eprint/604

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