Icard, Philippe and Simula, Luca and Zahn, Grit and Alifano, Marco and Mycielska, Maria E. (2023) The dual role of citrate in cancer. ELSEVIER, AMSTERDAM.
Full text not available from this repository. (Request a copy)Abstract
Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where it performs several functions. In normal cells, citrate sustains protein acetylation, lipid synthesis, gluconeogenesis, insulin secretion, bone tissues formation, spermatozoid mobility, and immune response. Dysregulation of citrate metabolism is implicated in several pathologies, including cancer. Here we discuss how cancer cells use citrate to sustain their proliferation, survival, and metastatic progression. Also, we propose two paradoxically opposite strategies to reduce tumour growth by targeting citrate metabolism in preclinical models. In the first strategy, we propose to administer in the tumor microenvironment a high amount of citrate, which can then act as a glycolysis inhibitor and apoptosis inducer, whereas the other strategy targets citrate transporters to starve cancer cells from citrate. These strategies, effective in several preclinical in vitro and in vivo cancer models, could be exploited in clinics, particularly to increase sensibility to current anti-cancer agents.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | FATTY-ACID OXIDATION; PROTEIN-KINASE-B; TUMOR-GROWTH; REDUCTIVE CARBOXYLATION; MITOCHONDRIAL CITRATE; AEROBIC GLYCOLYSIS; ENERGY-METABOLISM; ANTICANCER AGENT; GENE-EXPRESSION; CELL-GROWTH; Cancer; Citrate; pmCiC; Drug resistance; Warburg effect |
| Subjects: | 500 Science > 500 Natural sciences & mathematics |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 14:46 |
| Last Modified: | 30 Jan 2024 14:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60400 |
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