Mack, Matthias and Yanagita, Motoko (2015) Origin of myofibroblasts and cellular events triggering fibrosis. KIDNEY INTERNATIONAL, 87 (2). pp. 297-307. ISSN 0085-2538, 1523-1755
Full text not available from this repository. (Request a copy)Abstract
Renal fibrosis is a major hallmark of chronic kidney disease that is considered to be a common end point of various types of renal disease. To date, the biological meaning of fibrosis during the progression of chronic kidney diseases is unknown and possibly depends on the cell type contributing to extracellular matrix production. During the past decade, the origin of myofibroblasts in the kidney has been intensively investigated. Determining the origins of renal myofibroblasts is important because these might account for the heterogeneous characteristics and behaviors of myofibroblasts. Current data strongly suggest that collagen-producing myofibroblasts in the kidney can be derived from various cellular sources. Resident renal fibroblasts and cells of hematopoietic origin migrating into the kidney seem to be the most important ancestors of myofibroblasts. It is likely that both cell types communicate with each other and also with other cell types in the kidney. In this review, we will discuss the current knowledge on the origin of scar-producing myofibroblasts and cellular events triggering fibrosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIPHERAL-BLOOD FIBROCYTES; RENAL INTERSTITIAL FIBROSIS; INDUCED PULMONARY-FIBROSIS; TO-MESENCHYMAL TRANSITION; MARROW-DERIVED CELLS; SERUM AMYLOID-P; ERYTHROPOIETIN-PRODUCING CELLS; GROWTH-FACTOR-BETA; BONE-MARROW; KIDNEY FIBROSIS; end-stage kidney disease; erythropoietin; fibroblast; fibrosis; kidney disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Aug 2020 08:35 |
| Last Modified: | 14 Aug 2020 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6045 |
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