Schulze, Arik Bernard and Mohr, Michael and Sackarnd, Jan and Schmidt, Lars Henning and Tepasse, Phil-Robin and Rosenow, Felix and Evers, Georg (2023) Risk Factors in HIV-1 Positive Patients on the Intensive Care Unit: A Single Center Experience from a Tertiary Care Hospital. VIRUSES-BASEL, 15 (5): 1164. ISSN , 1999-4915
Full text not available from this repository. (Request a copy)Abstract
HIV-positive patients with acquired immunodeficiency syndrome (AIDS) often require treatment on intensive care units (ICUs). We aimed to present data from a German, low-incidence region cohort, and subsequently evaluate factors measured during the first 24 h of ICU stay to predict short- and long-term survival, and compare with data from high-incidence regions. We documented 62 patient courses between 2009 and 2019, treated on a non-operative ICU of a tertiary care hospital, mostly due to respiratory deterioration and co-infections. Of these, 54 patients required ventilatory support within the first 24 h with either nasal cannula/mask (n = 12), non-invasive ventilation (n = 16), or invasive ventilation (n = 26). Overall survival at day 30 was 77.4%. While ventilatory parameters (all p < 0.05), pH level (c/o 7.31, p = 0.001), and platelet count (c/o 164,000/ mu L, p = 0.002) were significant univariate predictors of 30-day and 60-day survival, different ICU scoring systems, such as SOFA score, APACHE II, and SAPS 2 predicted overall survival (all p < 0.001). Next to the presence or history of solid neoplasia (p = 0.026), platelet count (HR 6.7 for < 164,000/mu L, p = 0.020) and pH level (HR 5.8 for < 7.31, p = 0.009) remained independently associated with 30-day and 60-day survival in multivariable Cox regression. However, ventilation parameters did not predict survival multivariably.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERNATIONAL CONSENSUS DEFINITIONS; VIRUS-INFECTED PATIENTS; MANAGEMENT; SEPSIS; SCORE; PREVALENCE; ADMISSION; THERAPY; BURDEN; HIV; ICU; SAPS 2; SOFA; APACHE II |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2024 12:32 |
| Last Modified: | 23 Mar 2024 12:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60456 |
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