Taccone, Fabio Silvio and Rinaldi, Simone and Annoni, Filippo and Nobile, Leda and Di Nardo, Matteo and Maccieri, Jessica and Aliberti, Anna and Malfertheiner, Maximilan Valentin and Marudi, Andrea and Broman, Lars Mikael and Belliato, Mirko (2023) Safety and Effectiveness of Carbon Dioxide Removal CO2RESET Device in Critically Ill Patients. MEMBRANES, 13 (7): 686. ISSN , 2077-0375
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Background: In this retrospective study, we report the effectiveness and safety of a dedicated extracorporeal carbon dioxide removal (ECCO2R) device in critically ill patients. Methods: Adult patients on mechanical ventilation due to acute respiratory distress syndrome (ARDS) or decompensated chronic obstructive pulmonary disease (dCOPD), who were treated with a dedicated ECCO2R device (CO2RESET, Eurosets, Medolla, Italy) in case of hypercapnic acidemia, were included. Repeated measurements of CO2 removal (VCO2) at baseline and 1, 12, and 24 h after the initiation of therapy were recorded. Results: Over a three-year period, 11 patients received ECCO2R (median age 60 [43-72] years) 3 (2-39) days after ICU admission; nine patients had ARDS and two had dCOPD. Median baseline pH and PaCO2 levels were 7.27 (7.12-7.33) and 65 (50-84) mmHg, respectively. With a median ECCO2R blood flow of 800 (500-800) mL/min and maximum gas flow of 6 (2-14) L/min, the VCO2 at 12 h after ECCO2R initiation was 157 (58-183) mL/min. Tidal volume, respiratory rate, and driving pressure were significantly reduced over time. Few side effects were reported. Conclusions: In this study, a dedicated ECCO2R device provided a high VCO2 with a favorable risk profile.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY-DISTRESS-SYNDROME; PULMONARY COMPLICATIONS; TIDAL VOLUME; VENTILATION; respiratory failure; CO2 removal; extracorporeal; high blood flow; ARDS; complications |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2024 13:31 |
| Last Modified: | 23 Mar 2024 13:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60501 |
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