Kopf, Juliane and Gloeckner, Stefan and Althen, Heike and Cevada, Thais and Schecklmann, Martin and Dresler, Thomas and Kittel-Schneider, Sarah and Reif, Andreas (2023) Neural Responses to a Working Memory Task in Acute Depressed and Remitted Phases in Bipolar Patients. BRAIN SCIENCES, 13 (5): 744. ISSN , 2076-3425
Full text not available from this repository. (Request a copy)Abstract
(1) Cognitive impairments such as working memory (WM) deficits are amongst the most common dysfunctions characterizing bipolar disorder (BD) patients, severely contributing to functional impairment. We aimed to investigate WM performance and associated brain activation during the acute phase of BD and to observe changes in the same patients during remission. (2) Frontal brain activation was recorded using functional near-infrared spectroscopy (fNIRS) during n-back task conditions (one-back, two-back and three-back) in BD patients in their acute depressive (n = 32) and remitted (n = 15) phases as well as in healthy controls (n = 30). (3) Comparison of BD patients during their acute phase with controls showed a trend (p = 0.08) towards lower dorsolateral prefrontal cortex (dlPFC) activation. In the remitted phase, BD patients showed lower dlPFC and ventrolateral prefrontal cortex (vlPFC) activation (p = 0.02) compared to controls. No difference in dlPFC and vlPFC activation between BD patients' phases was found. (4) Our results showed decreased working memory performance in BD patients during the working memory task in the acute phase of disease. Working memory performance improved in the remitted phase of the disease but was still particularly attenuated for the more demanding conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FUNCTIONAL NEUROANATOMY; COGNITIVE DEFICITS; DISORDER; RELIABILITY; ACTIVATION; BRAIN; METAANALYSIS; OXYGENATION; PERFORMANCE; IMPAIRMENT; verbal n-back; fNIRS; prefrontal cortex; cognitive deficits; bipolar disorder; remitted; acute phase |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 14:17 |
| Last Modified: | 30 Jan 2024 14:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60517 |
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