Greinix, Hildegard T. and Kuzmina, Zoya and Weigl, Roman and Koermoczi, Ulrike and Rottal, Arno and Wolff, Daniel and Kralj, Mateja and Kalhs, Peter and Mitterbauer, Margit and Rabitsch, Werner and Edinger, Matthias and Holler, Ernst and Pickl, Winfried F. (2015) CD19(+)CD21(low) B Cells and CD4(+)CD45RA(+)CD31(+) T Cells Correlate with First Diagnosis of Chronic Graft-versus-Host Disease. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 21 (2). pp. 250-258. ISSN 1083-8791, 1523-6536
Full text not available from this repository. (Request a copy)Abstract
Chronic graft-versus-host disease (cGVHD) is a serious and frequent complication of allogeneic hematopoietic stem cell transplantation (HCT). Currently, no biomarkers for prediction and diagnosis of cGVHD are available. We performed a large prospective study focusing on noninvasive biomarkers for National Institutes of Health-defined cGVHD patients (n = 163) in comparison to time-matched HCT recipients who never experienced cGVHD (n = 64), analyzed from day 100 after HCT. In logistic regression analysis, CD19(+)CD21(low) B cells (P = .002; hazard ratio [HR.], 3.31; 95% confidence interval [CI], 1.53 to 7.17) and CD4(+)CD45RA(+)CD31(+) T cells (P < .001; HR, 3.88; 95% CI, 1.88 to 7.99) assessed on day 100 after HCT were significantly associated with subsequent development of cGVHD, independent of clinical parameters. A significant association with diagnosis of cGVHD was only observed for CD19(+)CD21(low) B cells (P = .008; HR, 3.00; 95% CI, 1.33 to 6.75) and CD4(+)CD45RA(+)CD31(+) T cells (P = .017; HR, 2.80; 95% CI, 1.19 to 6.55). CD19(+)CD21(low) B cells were found to have the highest discriminatory value with an area under the receiver operating curve of .77 (95% CI, .64 to .90). Our results demonstrate that CD19(+)CD21(low) B cells and CD4(+)CD45RA(+)CD31(+) T cells are significantly elevated in patients with newly diagnosed cGVHD. (C) 2015 American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONSENSUS DEVELOPMENT PROJECT; WORKING GROUP-REPORT; CHRONIC GVHD; BRONCHIOLITIS OBLITERANS; PERIPHERAL-BLOOD; CLINICAL-TRIALS; EXCESS BAFF; EXPRESSION; LYMPHOCYTES; NAIVE; Chronic graft-versus-host disease; Biomarker; B cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jul 2019 08:08 |
| Last Modified: | 25 Jul 2019 08:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6052 |
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