Abdelrahman, Omar and Topka, Marius and Zhang, Yao and Bock, Antonia and Loerner, Johannes and Jungbauer, Rebecca and Hotfiel, Thilo and Paulsen, Friedrich and Hammer, Christian M. (2024) Suitability of Slaughterhouse-Acquired Pig Eyes as Model Systems for Refractive Ultraviolet and Infrared Femtosecond Laser Research. CURRENT EYE RESEARCH, 49 (4). pp. 401-409. ISSN 0271-3683, 1460-2202
Full text not available from this repository. (Request a copy)Abstract
PurposeTo elucidate whether it is feasible to use porcine eyes from scalded, abattoir-acquired animals for refractive femtosecond laser research.MethodsAn infrared laser (FS 200) and an ultraviolet laser (prototype version) were tested for their applicability on scalded pig eyes. Fifty porcine eyes were divided into two equally-sized groups and assigned to either the infrared or the ultraviolet laser. Both laser groups were comprised of five subgroups of n = 5 eyes each. Group A: non-scalded eyes (negative control); group B: eyes taken from tunnel-scalded animals; group C1: eyes taken from tank-scalded animals without opaque corneal lesion; group C2: eyes taken from animals with opaque corneal lesion; group D: eyes scalded in toto in the laboratory (positive control). In each group the lasers were employed to create a stromal flap. The quality of the laser cuts and the resulting flap beds, as well as of the porcine corneas themselves, was examined by anterior segment optical coherence tomography and scanning electron microscopy.ResultsAll scalded specimens exhibited substantial corneal swelling, most pronounced in group C2. After ultraviolet laser application, the tank- and tunnel-scalded samples displayed marked irregularities and an increased degree of surface roughness in the flap beds. After infrared laser application, this was only the case in the tank-scalded specimens.ConclusionIt is not recommended to use eyes taken from scalded pigs for ultraviolet femtosecond laser experiments. For infrared femtosecond lasers, eyes taken from tunnel-scalded animals may represent an acceptable alternative, if non-scalded eyes are not available.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NANOSCALE TOPOGRAPHY; CORNEAL EPITHELIUM; BASEMENT-MEMBRANE; COLLAGEN; Femtosecond laser; refractive surgery; porcine eyes; cornea; abattoir |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2024 07:03 |
| Last Modified: | 04 Mar 2025 06:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60522 |
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