Unsoeld, Bernhard and Teucher, Nils and Didie, Michael and Sossalla, Samuel and Jacobshagen, Claudius and Seidler, Tim and Schillinger, Wolfgang and Hasenfuss, Gerd (2015) Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice. CARDIOVASCULAR THERAPEUTICS, 33 (1). pp. 20-26. ISSN 1755-5914, 1755-5922
Full text not available from this repository. (Request a copy)Abstract
BackgroundPantoprazole has been shown to exert a negative inotropic effect in isolated myocardium. The purpose of this study was to evaluate the hemodynamic effects of pantoprazole in vivo in healthy myocardium and in the setting of heart failure. Methods and ResultsHealthy mice and mice with heart failure 4weeks after myocardial infarction induced by permanent LAD ligation were instrumented with a Millar Mikrotip conductance catheter to record pressure-volume loops. Pantoprazole was infused at rates of 3 and 10mg/kg/min intravenously, and hemodynamic parameters were recorded. Infusion of pantoprazole at increasing rates lead to a significant decline of end systolic LV pressure by decreasing heart rate, myocardial contractility and arterial elastance. These effects were quick, beginning immediately with the infusion and usually reaching a plateau after 2 or 3min of infusion. The effects on blood pressure and heart rate were of comparable size in healthy mice and mice with MI. However, in sham-operated mice, there was a compensatory increase in stroke volume that sufficed to maintain cardiac output at a constant level, which was missing in mice with MI. In 4 of 13 mice with MI infusion of 10mg/kg/min pantoprazole lead to pump failure, which was lethal in 2 of these animals. ConclusionAt higher infusion rates, pantoprazole is able to induce negative hemodynamic responses. In particular, in the setting of heart failure, these effects can lead to significant impairment of cardiac function. Therefore, high infusion rates of pantoprazole should be avoided especially in heart failure patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTON-PUMP INHIBITORS; ATPASE; MYOCARDIUM; OMEPRAZOLE; RISK; H+; LANSOPRAZOLE; RELAXATION; INOTROPY; Chronotrpy; Conductance catheter; Inotropy; Ischemic heart disease; Mouse; Myocardial infarction; Proton pump inhibitor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jul 2019 08:09 |
| Last Modified: | 25 Jul 2019 08:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6053 |
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