Malfertheiner, Maximilian V. V. and Garrett, Ashlen and Passmore, Margaret and Haymet, Andrew B. B. and Webb, Richard I. I. and Von Bahr, Viktor and Millar, Jonathan E. E. and Schneider, Bailey A. A. and Obonyo, Nchafatso G. G. and Black, Debra and Bouquet, Mahe and Bartnikowski, Nicole and Suen, Jacky Y. Y. and Fraser, John F. F. (2023) The effects of nitric oxide on coagulation and inflammation in ex vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass. ARTIFICIAL ORGANS, 47 (10). pp. 1581-1591. ISSN 0160-564X, 1525-1594
Full text not available from this repository. (Request a copy)Abstract
BackgroundExtracorporeal life support (ECLS) has extensive applications in managing patients with acute cardiac and pulmonary failure. Two primary modalities of ECLS, cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO), include several similarities in their composition, complications, and patient outcomes. Both CPB and ECMO pose a high risk of thrombus formation and platelet activation due to the large surface area of the devices and bleeding due to system anticoagulation. Therefore, novel methods of anticoagulation are needed to reduce the morbidity and mortality associated with extracorporeal support. Nitric oxide (NO) has potent antiplatelet properties and presents a promising alternative or addition to anticoagulation with heparin during extracorporeal support.MethodsWe developed two ex vivo models of CPB and ECMO to investigate NO effects on anticoagulation and inflammation in these systems.ResultsSole addition of NO as an anticoagulant was not successful in preventing thrombus formation in the ex vivo setups, therefore a combination of low-level heparin with NO was used. Antiplatelet effects were observed in the ex vivo ECMO model when NO was delivered at 80 ppm. Platelet count was preserved after 480 min when NO was delivered at 30 ppm.ConclusionCombined delivery of NO and heparin did not improve haemocompatibility in either ex vivo model of CPB and ECMO. Anti-inflammatory effects of NO in ECMO systems have to be evaluated further.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; anticoagulation; cardiopulmonary bypass; extracorporeal life support; extracorporeal membrane oxygenation; mechanical circulatory support; nitric oxide; thrombosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2024 06:44 |
| Last Modified: | 26 Mar 2024 06:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60531 |
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