Ehnert, Sabrina and Schreiner, Anna J. and Seeliger, Claudine and Ecker, Josef and Springer, Fabian and Liebisch, Gerhard and Hemmann, Philipp and Histing, Tina and Nussler, Andreas K. (2023) Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density. EXCLI JOURNAL, 22. pp. 207-220. ISSN 1611-2156
Full text not available from this repository. (Request a copy)Abstract
There is general consent that with decreasing bone mineral density the amount of marrow adipose tissue increases. While image-based techniques, claim an increase in saturated fatty acids responsible for this effect, this study shows an increase in both saturated and unsaturated fatty acids in the bone marrow. Using fatty acid methyl ester gas chromatography-mass spectrometry, characteristic fatty acid patterns for patients with normal BMD (N = 9), osteopenia (N = 12), and osteoporosis (N = 9) have been identified, which differ between plasma, red bone marrow and yellow bone marrow. Selected fatty acids, e.g. FA10:0, FA14:1, or FA16:1 n-7 in the bone marrow or FA18:0, FA18:1 n-9, FA18:1 n-7, FA20:0, FA20:1 n-9, or FA20:3 n-6 in the plasma, correlated with osteoclast activity, suggesting a possible mechanism how these fatty acids may interfere with BMD. Although several fatty acids correlated well with the osteoclast activity and BMD, there was not a single fatty acid contained in our fatty acid profile that can be claimed for controlling BMD, a fact that may be attributed to the genetic heterogeneity of the patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INBRED STRAINS; OLEIC-ACID; DIFFERENTIATION; CELLS; WOMEN; Bone mineral density; fatty acid composition; bone marrow; saturated fatty acids; unsaturated fatty acids; Tartrate-Resistant Acidic Phosphatase (TRAP5b) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2024 08:57 |
| Last Modified: | 20 Mar 2024 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60532 |
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