Luczak, Michal W. and Dzaman, Karolina and Zareba, Lukasz and Czerwaty, Katarzyna and Siewiera, Jacek and Gluszko, Alicja and Olszewska, Ewa and Brzost, Jacek and Kantor, Ireneusz and Szczepanski, Miroslaw J. and Ludwig, Nils (2023) HMGB1 Carried by Small Extracellular Vesicles Potentially Plays a Role in Promoting Acquired Middle Ear Cholesteatoma. DIAGNOSTICS, 13 (22): 3469. ISSN , 2075-4418
Full text not available from this repository. (Request a copy)Abstract
Cholesteatoma is a specific medical condition involving the abnormal, non-cancerous growth of skin-like tissue in the middle ear, potentially leading to a collection of debris and even infections. The receptor for advanced glycation (RAGE) and its ligand, high-mobility box 1 (HMGB1), are both known to be overexpressed in cholesteatoma and play a potential role in the pathogenesis of the disease. In this study, we investigated the role of small extracellular vesicles (sEVs) in carrying HMGB1 and inducing disease-promoting effects in cholesteatoma. No significant differences in the concentration of isolated sEVs in the plasma of cholesteatoma patients (n = 17) and controls (n = 22) were found (p > 0.05); however, cholesteatoma-derived sEVs carried significantly higher levels of HMGB1 (p < 0.05). In comparison to sEVs isolated from the plasma of controls, cholesteatoma-derived sEVs significantly enhanced keratinocyte proliferation and IL-6 production (p < 0.05), potentially by engaging multiple activation pathways including MAPKp44/p42, STAT3, and the NF-kappa B pathway. Thus, HMGB1(+) sEVs emerge as a novel factor potentially promoting cholesteatoma progression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLYCATION END-PRODUCTS; 1 PROTEIN; EXPRESSION; RHINOSINUSITIS; KERATINOCYTES; INDUCTION; RECEPTOR; RELEASE; MARKERS; GERBIL; small extracellular vesicles; cholesteatoma; middle ear; exosomes; HMGB1; RAGE; chronic otitis media |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2024 06:47 |
| Last Modified: | 26 Mar 2024 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60533 |
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