Lips, Andrea and Calvano Kuechler, Erika and Ribeiro Madalena, Isabela and Nivoloni Tannure, Patricia and Santos Antunes, Leonardo and Azeredo Alves Antunes, Livia and Castro Costa, Marcelo and Proff, Peter and Kirschneck, Christian and Baratto-Filho, Flares (2023) Non-syndromic supernumerary teeth and association with a self-reported family history of cancer. JOURNAL OF OROFACIAL ORTHOPEDICS-FORTSCHRITTE DER KIEFERORTHOPADIE. ISSN 1434-5293, 1615-6714
Full text not available from this repository.Abstract
Background Supernumerary teeth are an alteration of dental developmental and result in the formation of teeth above the usual number. Epidemiologic studies suggested that patients with dentofacial anomalies and their family members may present an increased risk of developing cancer, including female breast cancer and gynecologic cancers. These observations indicate that genetic alterations that result in dental anomalies may be related to cancer development. Thus, the aim of the present study was to evaluate the association between supernumerary teeth and a family history of female breast cancer and gynecologic cancers.Methods The diagnosis of supernumerary teeth was based on clinical and radiographic examinations. For data collection, a questionnaire asking for information regarding ethnicity, age, gender, and self-reported family history of cancer up to the second generation was used. Statistical analysis was performed using the X-2 test and Fisher's exact test with an established alpha of 5%.Results A total of 344 patients were included; 47 of them had one or more non-syndromic supernumerary teeth (not associated with any syndrome or cleft lip and palate) and 297 were control patients. Age, ethnicity, and gender distribution were not statistically different between the group with supernumerary teeth and the control group (p > 0.05). The supernumerary teeth were most commonly observed in the incisors area. Breast cancer (n = 17) was the most commonly self-reported type of cancer, followed by uterine cervical (n = 10), endometrial (n = 2), and ovarian (n = 1) cancers. Endometrial cancer was significantly associated with the diagnosis of supernumerary teeth (p = 0.017).Conclusion This study suggests that patients with supernumerary teeth possess a higher risk of having family members with endometrial cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OVARIAN-CANCER; TOOTH AGENESIS; MUTATIONS; RUNX2; Endometrial neoplasms; Breast neoplasms; Uterine cervical neoplasms; Ovarian neoplasms; Dentofacial deformities |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2024 05:24 |
| Last Modified: | 20 Mar 2024 05:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60563 |
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