Hartmann, Steffi and Banys-Paluchowski, Maggie and Stickeler, Elmar and de Boniface, Jana and Gentilini, Oreste Davide and Kontos, Michalis and Seitz, Stephan and Kaltenecker, Gabriele and Waernberg, Fredrik and Zetterlund, Linda Holmstrand and Kolberg, Hans-Christian and Froehlich, Sarah and Kuehn, Thorsten (2023) Applicability of magnetic seeds for target lymph node biopsy after neoadjuvant chemotherapy in initially node-positive breast cancer patients: data from the AXSANA study. BREAST CANCER RESEARCH AND TREATMENT, 202. pp. 497-504. ISSN 0167-6806, 1573-7217
Full text not available from this repository. (Request a copy)Abstract
PurposeCurrently, various techniques are available to mark and selectively remove initially suspicious axillary lymph nodes (target lymph nodes, TLNs) in breast cancer patients receiving neoadjuvant chemotherapy (NACT). To date, limited data are available on whether the use of magnetic seeds (MS) is suitable for localizing TLNs. This study aimed to investigate the feasibility of MS in patients undergoing target lymph node biopsy (TLNB) or targeted axillary dissection (TAD) after NACT.MethodsProspective data from the ongoing multicentric AXSANA study were extracted from selected patients in whom the TLN had been marked with an MS before NACT and who were enrolled from June 2020 to June 2023. The endpoints of the analysis were the detection rate, the rate of lost markers, and the potential impairment on magnetic resonance imaging (MRI) assessment.ResultsIn 187 patients from 27 study sites in seven countries, MS were placed into the TLN before NACT. In 151 of these, post-NACT surgery had been completed at the time of analysis. In 146 patients (96.0%), a TLN could successfully be detected. In three patients, the seed was removed but no lymphoid tissue was detected on histopathology. The rate of lost markers was 1.2% (2 out of 164 MS). In 15 out of 151 patients (9.9%), MRI assessment was reported to be compromised by MS placement.ConclusionMS show excellent applicability for TLNB/TAD when inserted before NACT with a high DR and a low rate of lost markers. Axillary MS can impair MRI assessment of the breast.Trial registration numberNCT04373655 (date of registration May 4, 2020).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AXILLARY DISSECTION; LOCALIZATION; MAGSEED; Breast cancer; Neoadjuvant chemotherapy; Target lymph node; Targeted axillary dissection; Magnetic seed |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2024 05:40 |
| Last Modified: | 07 May 2024 05:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60586 |
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