Juergens, Julian H. W. and Schulz, Nadine and Wybranski, Christian and Seidensticker, Max and Streit, Sebastian and Brauner, Jan and Wohlgemuth, Walter A. and Deuerling-Zheng, Yu and RickeMd, Jens and Dudeck, Oliver (2015) Time-Resolved Perfusion Imaging at the Angiography Suite Preclinical Comparison of a New Flat-Detector Application to Computed Tomography Perfusion. INVESTIGATIVE RADIOLOGY, 50 (2). pp. 108-113. ISSN 0020-9996, 1536-0210
Full text not available from this repository. (Request a copy)Abstract
Objectives: The objective of this study was to compare the parameter maps of a new flat-panel detector application for time-resolved perfusion imaging in the angiography room (FD-CTP) with computed tomography perfusion (CTP) in an experimental tumor model. Materials and Methods: Twenty-four VX2 tumors were implanted into the hind legs of 12 rabbits. Three weeks later, FD-CTP (Artis zeego; Siemens) and CTP (SOMATOM Definition AS +; Siemens) were performed. The parameter maps for the FD-CTP were calculated using a prototype software, and those for the CTP were calculated with VPCT-body software on a dedicated syngo Multi-Modality Workplace. The parameters were compared using Pearson product-moment correlation coefficient and linear regression analysis. Results: The Pearson product-moment correlation coefficient showed good correlation values for both the intratumoral blood volume of 0.848 (P < 0.01) and the blood flow of 0.698 (P < 0.01). The linear regression analysis of the perfusion between FD-CTP and CTP showed for the blood volume a regression equation y = 4.44x + 36.72 (P < 0.01) and for the blood flow y = 0.75x + 14.61 (P < 0.01). Conclusions: This preclinical study provides evidence that FD-CTP allows a time-resolved (dynamic) perfusion imaging of tumors similar to CTP, which provides the basis for clinical applications such as the assessment of tumor response to locoregional therapies directly in the angiography suite.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CEREBRAL BLOOD-VOLUME; SQUAMOUS-CELL CARCINOMA; ARM CT MEASUREMENT; HEPATOCELLULAR-CARCINOMA; RADIATION-THERAPY; LIVER METASTASES; Y-90 RADIOEMBOLIZATION; RESIN-MICROSPHERES; TUMOR VASCULARITY; TARGETED THERAPY; flat-panel detector; flat-detector CT perfusion; CT perfusion; VX2 tumor; angiography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jul 2019 08:54 |
| Last Modified: | 25 Jul 2019 08:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6063 |
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