Bubeck, Alena M. and Urbain, Paul and Horn, Cathrine and Jung, Anna S. and Ferrari, Lisa and Ruple, Hannah K. and Podlesny, Daniel and Zorn, Stefanie and Laupsa-Borge, Johnny and Jensen, Caroline and Lindseth, Inge and Lied, Gulen Arslan and Dierkes, Jutta and Mellgren, Gunnar and Bertz, Hartmut and Matysik, Silke and Krautbauer, Sabrina and Liebisch, Gerhard and Schoett, Hans-Frieder and Dankel, Simon N. and Fricke, W. Florian (2023) High-fat diet impact on intestinal cholesterol conversion by the microbiota and serum cholesterol levels. ISCIENCE, 26 (9): 107697. ISSN , 2589-0042
Full text not available from this repository. (Request a copy)Abstract
Cholesterol-to-coprostanol conversion by the intestinal microbiota has been suggested to reduce intestinal and serum cholesterol availability, but the relationship between intestinal cholesterol conversion and the gut microbiota, dietary habits, and serum lipids has not been characterized in detail. We measured conserved proportions of cholesterol high and low-converter types in individuals with and without obesity from two distinct, independent low-carbohydrate high-fat (LCHF) dietary intervention studies. Across both cohorts, cholesterol conversion increased in previous low-converters after LCHF diet and was positively correlated with the fecal relative abundance of Eubacterium coprostanoligenes. Lean cholesterol high-converters had increased serum triacylglycerides and decreased HDL-C levels before LCHF diet and responded to the intervention with increased LDL-C, independently of fat, cholesterol, and saturated fatty acid intake. Our findings identify the cholesterol high-converter type as a microbiome marker, which in metabolically healthy lean individuals is associated with increased LDL-C in response to LCHF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EUBACTERIUM-COPROSTANOLIGENES ATCC-51222; BILE-ACIDS; GUT MICROBIOME; CARBOHYDRATE; FECES; BACTERIUM; PATTERNS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 10:47 |
| Last Modified: | 30 Jan 2024 10:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60649 |
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