Beijert, Irene J. and Hentschel, Anouk E. and Bruendl, Johannes and Comperat, Eva M. and Plass, Karin and Rodriguez, Oscar and Henriquez, Jose D. Subiela and Hernandez, Virginia and de la Pena, Enrique and Alemany, Isabel and Turturica, Diana and Pisano, Francesca and Soria, Francesco and Capoun, Otakar and Bauerova, Lenka and Pesl, Michael and Bruins, H. Maxim and Runneboom, Willemien and Herdegen, Sonja and Breyer, Johannes and Brisuda, Antonin and Calatrava, Ana and Rubio-Briones, Jose and Seles, Maximilian and Mannweiler, Sebastian and Bosschieter, Judith and Kusuma, Venkata R. M. and Ashabere, David and Huebner, Nicolai and Cotte, Juliette and Contieri, Roberto and Mertens, Laura S. and Claps, Francesco and Masson-Lecomte, Alexandra and Liedberg, Fredrik and Cohen, Daniel and Lunelli, Luca and Cussenot, Olivier and El Sheikh, Soha and Volanis, Dimitrios and Cote, Jean-Francois and Roupret, Morgan and Haitel, Andrea and Shariat, Shahrokh F. and Mostafid, A. Hugh and Nieuwenhuijzen, Jakko A. and Zigeuner, Richard and Dominguez-Escrig, Jose L. and Hacek, Jaromir and Zlotta, Alexandre R. and Burger, Maximilian and Evert, Matthias and van de Kaa, Christina A. and van der Heijden, Antoine G. and Kiemeney, Lambertus A. L. M. and Soukup, Viktor and Molinaro, Luca and Gontero, Paolo and Llorente, Carlos and Algaba, Ferran and Palou, Joan and N'Dow, James and Ribal, Maria J. and van der Kwast, Theo H. and Babjuk, Marko and Sylvester, Richard J. and van Rhijn, Bas W. G. (2024) Second TURB, restaging TURB or repeat TURB in primary T1 non-muscle invasive bladder cancer: impact on prognosis? INTERNATIONAL UROLOGY AND NEPHROLOGY, 56. pp. 1323-1333. ISSN 0301-1623, 1573-2584
Full text not available from this repository. (Request a copy)Abstract
PurposeA re-transurethral resection of the bladder (re-TURB) is a well-established approach in managing non-muscle invasive bladder cancer (NMIBC) for various reasons: repeat-TURB is recommended for a macroscopically incomplete initial resection, restaging-TURB is required if the first resection was macroscopically complete but contained no detrusor muscle (DM) and second-TURB is advised for all completely resected T1-tumors with DM in the resection specimen. This study assessed the long-term outcomes after repeat-, second-, and restaging-TURB in T1-NMIBC patients.MethodsIndividual patient data with tumor characteristics of 1660 primary T1-patients (muscle-invasion at re-TURB omitted) diagnosed from 1990 to 2018 in 17 hospitals were analyzed. Time to recurrence, progression, death due to bladder cancer (BC), and all causes (OS) were visualized with cumulative incidence functions and analyzed by log-rank tests and multivariable Cox-regression models stratified by institution.ResultsMedian follow-up was 45.3 (IQR 22.7-81.1) months. There were no differences in time to recurrence, progression, or OS between patients undergoing restaging (135 patients), second (644 patients), or repeat-TURB (84 patients), nor between patients who did or who did not undergo second or restaging-TURB. However, patients who underwent repeat-TURB had a shorter time to BC death compared to those who had second- or restaging-TURB (multivariable HR 3.58, P = 0.004).ConclusionPrognosis did not significantly differ between patients who underwent restaging- or second-TURB. However, a worse prognosis in terms of death due to bladder cancer was found in patients who underwent repeat-TURB compared to second-TURB and restaging-TURB, highlighting the importance of separately evaluating different indications for re-TURB.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL-CARCINOMA; TRANSURETHRAL RESECTION; RECURRENCE; SURVIVAL; Non-muscle invasive bladder cancer; Re-TURB; Second TURB; Repeat TURB; Restaging TURB; Prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2024 07:02 |
| Last Modified: | 04 Mar 2025 07:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60687 |
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