Passweg, Jakob R. and Baldomero, Helen and Ciceri, Fabio and Corbacioglu, Selim and de la Camara, Rafael and Dolstra, Harry and Glass, Bertram and Greco, Raffaella and McLornan, Donal P. and Neven, Benedicte and de Latour, Regis Peffault and Peric, Zinaida and Ruggeri, Annalisa and Snowden, John A. and Sureda, Anna (2023) Hematopoietic cell transplantation and cellular therapies in Europe 2021. The second year of the SARS-CoV-2 pandemic. A Report from the EBMT Activity Survey. BONE MARROW TRANSPLANTATION, 58 (6). pp. 647-658. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
In 2021, 47,412 HCT (19,806 (42%) allogeneic and 27,606 (58%) autologous) in 43,109 patients were reported by 694 European centers. 3494 patients received advanced cellular therapies, 2524 of which were CAR-T treatments, an additional 3245 received DLI. Changes compared to the previous year were CAR-T treatment (+35%), allogeneic HCT +5.4%, autologous HCT +3.9%, more pronounced in non-malignant disorders. Main indications for allogeneic HCT were myeloid malignancies 10,745 (58%), lymphoid malignancies 5127 (28%) and non-malignant disorders 2501 (13%). Main indications for autologous HCT were lymphoid malignancies 22,129 (90%) and solid tumors 1635 (7%). In allogeneic HCT, use of haploidentical donors decreased by -0.9% while use of unrelated and sibling donors increased by +4.3% and +9%. Cord blood HCT decreased by -5.8%. Pediatric HCT increased overall by +5.6% (+6.9% allogeneic and +1.6% autologous). Increase in the use of CAR-T was mainly restricted to high-income countries. The drop in HCT activity reported in 2020 partially recovered in 2021, the second year of the SARS-CoV-2 pandemic. The transplant community confronted with the pandemic challenge, continued in providing patients access to treatment. This annual EBMT report reflects current activities useful for health care resource planning.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AUTOLOGOUS TRANSPLANT; RELAPSED DLBCL; T-CELLS; BLOOD |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Mar 2024 07:56 |
| Last Modified: | 13 Mar 2024 07:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60694 |
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