Rubenich, Dominique S. and de Souza, Priscila O. and Omizzollo, Natalia and Aubin, Mariana R. and Basso, Paulo J. and Silva, Luisa M. and da Silva, Eloisa M. and Teixeira, Fernanda C. and Gentil, Gabriela F. S. and Domagalski, Jordana L. and Cunha, Maico T. and Gadelha, Kerolainy A. and Diel, Leonardo F. and Gelsleichter, Nicolly E. and Rubenich, Aline S. and Lenz, Gabriela S. and de Abreu, Aline M. and Kroeff, Giselle M. and Paz, Ana H. and Visioli, Fernanda and Lamers, Marcelo L. and Wink, Marcia R. and Worm, Paulo V. and Araujo, Anelise B. and Sevigny, Jean and Camara, Niels O. S. and Ludwig, Nils and Braganhol, Elizandra (2023) Tumor-neutrophil crosstalk promotes <i>in vitro</i> and <i>in vivo</i> glioblastoma progression. FRONTIERS IN IMMUNOLOGY, 14: 1183465. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
IntroductionThe tumor microenvironment (TME) of glioblastoma (GB) is characterized by an increased infiltration of immunosuppressive cells that attenuate the antitumor immune response. The participation of neutrophils in tumor progression is still controversial and a dual role in the TME has been proposed. In this study, we show that neutrophils are reprogrammed by the tumor to ultimately promote GB progression. MethodsUsing in vitro and in vivo assays, we demonstrate the existence of bidirectional GB and neutrophil communication, directly promoting an immunosuppressive TME. Results and discussionNeutrophils have shown to play an important role in tumor malignancy especially in advanced 3D tumor model and Balb/c nude mice experiments, implying a time- and neutrophil concentration-dependent modulation. Studying the tumor energetic metabolism indicated a mitochondria mismatch shaping the TME secretome. The given data suggests a cytokine milieu in patients with GB that favors the recruitment of neutrophils, sustaining an anti-inflammatory profile which is associated with poor prognosis. Besides, glioma-neutrophil crosstalk has sustained a tumor prolonged activation via NETs formation, indicating the role of NF kappa B signaling in tumor progression. Moreover, clinical samples have indicated that neutrophil-lymphocyte ratio (NLR), IL-1 beta, and IL-10 are associated with poor outcomes in patients with GB. ConclusionThese results are relevant for understanding how tumor progression occurs and how immune cells can help in this process.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MITOCHONDRIAL-DNA; REGULATORY CELLS; CANCER; MICROENVIRONMENT; POPULATION; METABOLISM; MEDIATE; GLIOMAS; tumor associated neutrophils; glioblastoma; tumor microenvironment; cancer; neutrophil extracellular traps |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2024 06:33 |
| Last Modified: | 09 Apr 2024 06:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60698 |
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