Kjaergaard, Alisa D. and Krakauer, Jesse and Krakauer, Nir and Teumer, Alexander and Winkler, Thomas W. and Ellervik, Christina (2023) Allometric body shape indices, type 2 diabetes and kidney function: A two-sample Mendelian randomization study. DIABETES OBESITY & METABOLISM, 25 (7). pp. 1803-1812. ISSN 1462-8902, 1463-1326
Full text not available from this repository. (Request a copy)Abstract
Aim: To examine the association between body mass index (BMI)-independent allometric body shape indices and kidney function.Materials and methods: We performed a two-sample Mendelian randomization (MR) analysis, using summary statistics from UK Biobank, CKDGen and DIAGRAM. BMI-independent allometric body shape indices were: A Body Shape Index (ABSI), Waist-Hip Index (WHI) and Hip Index (HI). Kidney function outcomes were: urinary albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate and blood urea nitrogen. Furthermore, we investigated type 2 diabetes (T2D) as a potential mediator on the pathway to albuminuria. The main analysis was inverse variance-weighted random-effects MR in participants of European ancestry. We also performed several sensitivity MR analyses.Results: A 1-standard deviation (SD) increase in genetically predicted ABSI and WHI levels was associated with higher UACR (beta = 0.039 [95% confidence interval: 0.016, 0.063] log [UACR], P = 0.001 for ABSI, and beta = 0.028 [0.012, 0.044] log [UACR], P = 6 x 10(-4) for WHI) in women, but not in men. Meanwhile, a 1-SD increase in genetically predicted HI was associated with lower UACR in women (beta = -0.021 [-0.041, 0.000] log [UACR], P = 0.05) and in men (beta = -0.026 [-0.058, 0.005] log [UACR], P = 0.10). Corresponding estimates in individuals with diabetes were substantially augmented. Risk of T2D increased for genetically high ABSI and WHI in women (P < 6 x 10(-19)) only, but decreased for genetically high HI in both sexes (P < 9 x 10(-3)). No other associations were observed.Conclusions: Genetically high HI was associated with decreased risk of albuminuria, mediated through decreased T2D risk in both sexes. Opposite associations applied to genetically high ABSI and WHI in women only.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; ADIPOSITY; OBESITY; ALBUMINURIA; DISEASE; albuminuria; blood urea nitrogen; diabetes mellitus; type 2; glomerular filtration rate; kidney function tests; Mendelian randomization analysis; obesity; renal insufficiency; chronic |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 10:56 |
| Last Modified: | 30 Jan 2024 10:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60716 |
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