Grund, Johanna and Iben, Katharina and Reinke, Sarah and Buehnen, Ina and Pluetschow, Annette and Mueller-Meinhard, Berit and Garcia Marquez, Maria A. and Schloesser, Hans A. and von Tresckow, Bastian and Kellermeier, Fabian and Borchmann, Peter and Engert, Andreas and Broeckelmann, Paul J. and Klapper, Wolfram (2023) Low B-cell content is associated with a CD73-low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma. BRITISH JOURNAL OF HAEMATOLOGY, 201 (6). pp. 1097-1102. ISSN 0007-1048, 1365-2141
Full text not available from this repository. (Request a copy)Abstract
B-cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B-cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down-regulation of CD73 in HL with low B cells suggestive of an antibody-independent function of B cells in the TME of HL.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REVEALS; B-cells; hodgkins lymphoma; microenvironment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2024 06:51 |
| Last Modified: | 09 Apr 2024 06:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60720 |
Actions (login required)
 |
View Item |
