Winter, K. and Pfeil, Johanna Madeleine and Engmann, H. and Aisenbrey, S. and Lorenz, B. and Hufendiek, K. and Breuss, H. and Khattab, M. and Suesskind, D. and Kakkassery, V. and Lagreze, W. A. and Barth, Teresa and Liegl, R. and Bruender, M. C. and Skevas, C. and Goldammer, I. and Glitz, B. and Michalewicz, E. and Krohne, T. U. and Bartmann, I. R. and Stahl, A. (2024) Comparability of input parameters in the German Retina.net ROP registry and the EU-ROP registry - An exemplary comparison between 2011 and 2021. ACTA OPHTHALMOLOGICA, 102 (3). e314-e321. ISSN 1755-375X, 1755-3768
Full text not available from this repository. (Request a copy)Abstract
PurposeThe German Retina.net ROP registry and its Europe-wide successor, the EU-ROP registry, collect data from patients treated for ROP. This analysis compares input parameters of these two registries to establish a procedure for joint analyses of different registry data using exemplary datasets from the two registries.MethodsExemplary datasets from the two databases over a 1-year period each (German Retina.net ROP Registry, 2011, 22 infants; EU-ROP Registry, 2021, 44 infants) were compared. The parameters documented in the two databases were aligned and analysed regarding demographic parameters, treatment modalities, complications within first 24 h and retreatments.ResultsThe current analysis showed that data can be aligned for joint analyses with some adjustments within the data structure. The registry with more detailed data collection (EU-ROP) needs to be reduced regarding granularity in order to align the different registries, as the registry with lower granularity determines the level of analyses that can be performed in a comparative approach. In the exemplary datasets, we observed that the overall most common ROP severity in both registries was zone II, 3+ (2011: 70.5%; 2021: 65%), with decreasing numbers of clock hours showing preretinal neovascularisations (2011: 10-12 clock hours in 29% of cases, 2021: 4-6 clock hours in 38%). The most prevalent treatment method was laser coagulation in 2011 (75%) and anti-VEGF therapy in 2021 (86.1%). Within the anti-VEGF group, all patients were treated with bevacizumab in 2011 and with ranibizumab in 2021. Retreatment rates were comparable in 2011 and 2021.ConclusionData from two different ROP registries can be aligned and jointly analysed. The analysis reveals a paradigm shift in treatment modalities, from predominantly laser to anti-VEGF, and within the anti-VEGF group from bevacizumab to ranibizumab in Germany. In addition, there was a trend towards earlier treatment in 2021.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RETINOPATHY; PREMATURITY; EFFICACY; anti-VEGF; laser coagulation; observational study; registry; retinopathy of prematurity; ROP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2024 05:49 |
| Last Modified: | 11 Mar 2025 10:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60748 |
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