Shouval, Roni and Waters, Nicholas R. and Gomes, Antonio L. C. and Brambilla, Corrado Zuanelli and Fei, Teng and Devlin, Sean M. and Nguyen, Chi L. and Markey, Kate A. and Dai, Anqi and Slingerland, John B. and Clurman, Annelie G. and Fontana, Emily and Amoretti, Luigi A. and Wright, Roberta J. and Hohl, Tobias M. and Taur, Ying and Sung, Anthony D. and Weber, Daniela and Hashimoto, Daigo and Teshima, Takanori and Chao, Nelson J. and Holler, Ernst and Scordo, Michael and Giralt, Sergio A. and Perales, Miguel-Angel and Peled, Jonathan U. and van den Brink, Marcel R. M. (2023) Conditioning Regimens are Associated with Distinct Patterns of Microbiota Injury in Allogeneic Hematopoietic Cell Transplantation. CLINICAL CANCER RESEARCH, 29 (1). pp. 165-173. ISSN 1078-0432, 1557-3265
Full text not available from this repository. (Request a copy)Abstract
Purpose: The gut microbiota is subject to multiple insults in allogeneic hematopoietic cell transplantation (allo-HCT) recipients. We hypothesized that preparative conditioning regi-mens contribute to microbiota perturbation in allo-HCT.Experimental Design: This was a retrospective study that eval-uated the relationship between conditioning regimens exposure in 1,188 allo-HCT recipients and the gut microbiome. Stool samples collected from 20 days before transplantation up to 30 days after were profiled using 16S rRNA sequencing. Microbiota injury was quantified by changes in a-diversity.Results: We identified distinct patterns of microbiota injury that varied by conditioning regimen. Diversity loss was graded into three levels of conditioning-associated microbiota injury (CMBI) in a multivariable model that included antibiotic exposures. High -intensity regimens, such as total body irradiation (TBI)-thiotepa-cyclophosphamide, were associated with the greatest injury (CMBI III). In contrast, the nonmyeloablative regimen fludarabine- cyclophosphamide with low-dose TBI (Flu/Cy/TBI200) had a low-grade injury (CMBI I). The risk of acute GVHD correlated with CMBI degree. Pretransplant microbial compositions were best preserved with Flu/Cy/TBI200, whereas other regimens were associated with loss of commensal bacteria and expansion of Enterococcus.Conclusions: Our findings support an interaction between con-ditioning at the regimen level and the extent of microbiota injury.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; DIVERSITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2024 09:10 |
| Last Modified: | 09 Apr 2024 09:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60754 |
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