Bal, Christina and Pohl, Wolfgang and Milger, Katrin and Skowasch, Dirk and Schulz, Christian and Gappa, Monika and Koerner-Rettberg, Cordula and Jandl, Margret and Schmidt, Olaf and Zehetmayer, Sonja and Taube, Christian and Hamelmann, Eckard and Buhl, Roland and Korn, Stephanie and Idzko, Marco (2023) Characterization of Obesity in Severe Asthma in the German Asthma Net. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 11 (11). ISSN 2213-2198, 2213-2201
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Asthma is increasingly recognized as heterogeneous, characterized by different endotypes, with obesity not only a distinct phenotype but a risk factor for severe asthma.OBJECTIVE: We sought to understand the associations of obesity with relevant parameters of severe asthma, including asthma control, disease burden, and lung function.METHODS: The German Asthma Net registry is a multicenter international real-life registry capturing long-term follow-up data. This analysis included 2213 patients (52 +/- 16 years, 58% female, 29% with obesity [body mass index double dagger 30 kg/m2], 4.2 +/- 4.3 exacerbations/year). The primary analysis assessed relationships between BMI and variables through univariate tests, followed by a multiple regression model. Secondary outcomes regarded clinically relevant variables in relation to weight groups.RESULTS: Patients with obesity were more frequently female, more likely to have depression and gastroesophageal reflux, and suffered from worse asthma control, lower quality of life, reduced static lung volumes, more pronounced hypoxemia, and higher blood neutrophil counts, all statistically significant. Blood eosinophils, exhaled nitric oxide, and total IgE were independent of obesity. In the multiple regression analysis, obesity was significantly associated with more frequent reflux and depression, reduced static lung function values, older age, poor asthma control, and long-acting muscarinic antagonist therapy, and inversely associated with bronchiectasis and nonsmoking status.CONCLUSION: In this large, well-characterized cohort, we identified the association of obesity with a significantly higher disease burden and a similar portfolio of inflammation type 2 markers in patients with and without obesity; therefore, patients with obesity seem similarly eligible for the treatment with biologics targeting these disease endotypes. (c) 2023 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:3417-24)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; CLUSTER-ANALYSIS; CORTICOSTEROID-THERAPY; LUNG-FUNCTION; IMPAIRMENT; GUIDELINES; IMPACT; COHORT; Severe asthma; Obesity; BMI; Registry; Comorbid-ities; Lung function; Asthma control; Exacerbations; Biomarker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 10:47 |
| Last Modified: | 30 Jan 2024 10:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60776 |
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