Mikuteit, Marie and Zschaebitz, Stefanie and Stoehr, Christine and Herrmann, Edwin and Polifka, Iris and Agaimy, Abbas and Trojan, Lutz and Stroebel, Philipp and Becker, Frank and Wuelfing, Christian and Barth, Peter and Stoeckle, Michael and Staehler, Michael and Stief, Christian and Haferkamp, Axel and Hohenfellner, Markus and Duensing, Stefan and Macher-Goeppinger, Stephan and Wullich, Bernd and Noldus, Joachim and Brenner, Walburgis and Roos, Frederik and Walter, Bernhard and Otto, Wolfgang and Burger, Maximilian and Erlmeier, Maximillian and Schrader, Andres Jan and Hartmann, Arndt and Erlmeier, Franziska and Steffens, Sandra (2023) Evaluation of Gas 6 as a Prognostic Marker in Papillary Renal Cell Carcinoma. UROLOGIA INTERNATIONALIS, 107 (7). pp. 713-722. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Introduction: Growth arrest-specific protein 6 (Gas 6) is a ligand that plays a role in proliferation and migration of cells. For several tumor entities, high levels of Gas 6 are associated with poorer survival. We examined the prognostic role of Gas 6 in renal cell carcinoma (RCC), especially in papillary RCC (pRCC), which is still unclear. Methods: The patients' sample collection is a joint collaboration of the PANZAR consortium. Patients' medical history and tumor specimens were collected from n = 240 and n = 128 patients with type 1 and 2 pRCC, respectively. Expression of Gas 6 was determined by immunohistochemistry. Results: In total, Gas 6 staining was evaluable in 180 of 240 type 1 and 110 of 128 type 2 pRCC cases. Kaplan-Meier analysis disclosed no significant difference in 5-year overall survival for all pRCC nor either subtype. Also, Gas+ and Gas- groups did not significantly differ in any tumor or patient characteristics. Conclusion: Gas 6 was not found to be an independent prognostic marker in pRCC. Future studies are warranted to determine if Gas 6 plays a role as prognostic marker or therapeutic target in pRCC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AXL; EXPRESSION; CANCER; SURVIVAL; Prognosis; Gas 6; Papillary renal cell carcinoma; Survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Apr 2024 12:34 |
| Last Modified: | 18 Apr 2024 12:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60809 |
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