Torow, Natalia and Li, Ronghui and Hitch, Thomas Charles Adrian and Mingels, Clemens and Al Bounny, Shahed and van Best, Niels and Stange, Eva-Lena and Simons, Britta and Maie, Tiago and Ruettger, Lennart and Gubbi, Narasimha Murthy Keshava Prasad and Abbott, Darryl Adelaide and Benabid, Adam and Gadermayr, Michael and Runge, Solveig and Treichel, Nicole and Merhof, Dorit and Rosshart, Stephan Patrick and Jehmlich, Nico and Hand, Timothy Wesley and von Bergen, Martin and Heymann, Felix and Pabst, Oliver and Clavel, Thomas and Tacke, Frank and Lelouard, Hugues and Costa, Ivan Gesteira and Hornef, Mathias Walter (2023) M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch. IMMUNITY, 56 (6). 1220-+. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
Early-life immune development is critical to long-term host health. However, the mechanisms that determine the pace of postnatal immune maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches (PPs), the primary inductive site of intestinal immunity. Conventional type 1 and 2 dendritic cells (cDC1 and cDC2) and RORgt+ antigen-presenting cells (RORgt+ APC) exhibited sig-nificant age-dependent changes in subset composition, tissue distribution, and reduced cell maturation, sub-sequently resulting in a lack in CD4+ T cell priming during the postnatal period. Microbial cues contributed but could not fully explain the discrepancies in MNP maturation. Type I interferon (IFN) accelerated MNP maturation but IFN signaling did not represent the physiological stimulus. Instead, follicle-associated epithelium (FAE) M cell differentiation was required and sufficient to drive postweaning PP MNP maturation. Together, our results highlight the role of FAE M cell differentiation and MNP maturation in postnatal immune development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENDRITIC CELLS; GUT MICROBIOTA; EARLY-LIFE; DIARRHEAL DISEASE; RESPONSES; MOUSE; HOMEOSTASIS; INDUCTION; ALPHA; COLONIZATION; |
| Subjects: | 000 Computer science, information & general works > 004 Computer science |
| Divisions: | Informatics and Data Science |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 10:39 |
| Last Modified: | 30 Jan 2024 10:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60873 |
Actions (login required)
 |
View Item |
