Helm, Mark and Bohnsack, Markus T. and Carell, Thomas and Dalpke, Alexander and Entian, Karl-Dieter and Ehrenhofer-Murray, Ann and Ficner, Ralf and Hammann, Christian and Ho''bartner, Claudia and Ja''schke, Andres and Jeltsch, Albert and Kaiser, Stefanie and Klassen, Roland and Leidel, Sebastian A. and Marx, Andreas and Mo''rl, Mario and Meier, Jochen C. and Meister, Gunter and Rentmeister, Andrea and Rodnina, Marina and Roignant, Jean-Yves and Schaffrath, Raffael and Stadler, Peter and Stafforst, Thorsten (2023) Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications. ACS CHEMICAL BIOLOGY, 18 (12). pp. 2441-2449. ISSN 1554-8929, 1554-8937
Full text not available from this repository. (Request a copy)Abstract
The chemical biology of native nucleic acid modifications has seen an intense upswing, first concerning DNA modifications in the field of epigenetics and then concerning RNA modifications in a field that was correspondingly rebaptized epitranscriptomics by analogy. The German Research Foundation (DFG) has funded several consortia with a scientific focus in these fields, strengthening the traditionally well-developed nucleic acid chemistry community and inciting it to team up with colleagues from the life sciences and data science to tackle interdisciplinary challenges. This Perspective focuses on the genesis, scientific outcome, and downstream impact of the DFG priority program SPP1784 and offers insight into how it fecundated further consortia in the field. Pertinent research was funded from mid-2015 to 2022, including an extension related to the coronavirus pandemic. Despite being a detriment to research activity in general, the pandemic has resulted in tremendously boosted interest in the field of RNA and RNA modifications as a consequence of their widespread and successful use in vaccination campaigns against SARS-CoV-2. Funded principal investigators published over 250 pertinent papers with a very substantial impact on the field. The program also helped to redirect numerous laboratories toward this dynamic field. Finally, SPP1784 spawned initiatives for several funded consortia that continue to drive the fields of nucleic acid modification.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESSENGER-RNA; METHYLATION; N-1-METHYLADENOSINE; METHYLTRANSFERASE; 2'-O-METHYLATION; PROTEINS; POSITION; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Apr 2024 14:18 |
| Last Modified: | 18 Apr 2024 14:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60875 |
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