Huemer, Marie-Theres and Kluttig, Alexander and Fischer, Beate and Ahrens, Wolfgang and Castell, Stefanie and Ebert, Nina and Gastell, Sylvia and Joeckel, Karl-Heinz and Kaaks, Rudolf and Karch, Andre and Keil, Thomas and Kemmling, Yvonne and Krist, Lilian and Leitzmann, Michael and Lieb, Wolfgang and Meinke-Franze, Claudia and Michels, Karin B. and Mikolajczyk, Rafael and Moreno Velasquez, Ilais and Pischon, Tobias and Schipf, Sabine and Schmidt, Boerge and Schoettker, Ben and Schulze, Matthias B. and Stocker, Hannah and Teismann, Henning and Wirkner, Kerstin and Drey, Michael and Peters, Annette and Thorand, Barbara (2023) Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort-a comparison to the EWGSOP2 cut-off points. AGE AND AGEING, 52 (1): afac324. ISSN 0002-0729, 1468-2834
Full text not available from this repository. (Request a copy)Abstract
Background The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies. Objective Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample. Methods We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 x SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality. Results Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5x higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality. Conclusions Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HANDGRIP STRENGTH; QUALITY-ASSURANCE; NORMATIVE DATA; AGE; MOBILITY; FITNESS; grip strength; probable sarcopenia; European Working Group on Sarcopenia in Older People (EWGSOP); mortality; cut-off points |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Jan 2024 12:29 |
| Last Modified: | 31 Jan 2024 12:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60920 |
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