Averbuch, Dina and de la Camara, Rafael and Tridello, Gloria and Knelange, Nina Simone and Bykova, Tatiana A. and Ifversen, Marianne and Dobsinska, Veronika and Ayas, Mouhab and Hamidieh, Amir Ali and Pichler, Herbert and Perez-Martinez, Antonio and Cesaro, Simone and Sundin, Mikael and Badell, Isabel and Bader, Peter and Johansson, Jan-Erik and Mirci-Danicar, Oana and Sedlacek, Petr and Paillard, Catherine and Gibson, Brenda and Lawson, Sarah and Kroeger, Nicolaus and Corbacioglu, Selim and Mikulska, Malgorzata and Pinana, Jose Luis and Styczynski, Jan and Ljungman, Per (2023) Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: a prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study. BONE MARROW TRANSPLANTATION, 58 (5). pp. 558-566. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0-181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OUTCOMES; RECIPIENTS; COVID-19; STATES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 07:30 |
| Last Modified: | 30 Jan 2024 07:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60937 |
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