Weisshaar, Elke and Bentz, Philipp and Apfelbacher, Christian and Haufe, Eva and Heinrich, Luise and Heratizadeh, Annice and Abraham, Susanne and Harder, Inken and Kleinheinz, Andreas and Wollenberg, Andreas and Schaekel, Knut and Wiemers, Franca and Ertner, Julia and Augustin, Matthias and Wildberger, Julia and von Kiedrowski, Ralph and Worm, Margitta and Zink, Alexander and Effendy, Isaak and Asmussen, Andrea and Pawlak, Mario and Sticherling, Michael and Hilgers, Melanie and Handrick, Christiane and Quist, Sven and Schwarz, Beate and Bell, Magnus and Staubach-Renz, Petra and Hong-Weldemann, Sung-Hei and Homey, Bernhard and Bruecher, Jens-Joachim and Weidinger, Stephan and Werfel, Thomas and Schmitt, Jochen (2023) Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany. ACTA DERMATO-VENEREOLOGICA, 103: adv00854. ISSN 0001-5555, 1651-2057
Full text not available from this repository. (Request a copy)Abstract
TREATgermany is an investigator-initiated prospec-tive disease registry. It investigates physician-and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Der-matitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symp-toms (itch, sleep loss, depressive symptoms), thera-py courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 +/- 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The cur-rent analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the pre-vious 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong cor-relation was found with self-reported disease severi-ty as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assess-ments by the physician.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FATIGUE SEVERITY SCALE; TASK-FORCE; VALIDATION; ADULTS; RELIABILITY; LIFE; EASI; POEM; pruritus; quality of life; registry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 14:19 |
| Last Modified: | 30 Jan 2024 14:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60942 |
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