Budu-Aggrey, Ashley and Kilanowski, Anna and Sobczyk, Maria K. and Shringarpure, Suyash S. and Mitchell, Ruth and Reis, Kadri and Reigo, Anu and Maegi, Reedik and Nelis, Mari and Tanaka, Nao and Brumpton, Ben M. and Thomas, Laurent F. and Sole-Navais, Pol and Flatley, Christopher and Espuela-Ortiz, Antonio and Herrera-Luis, Esther and Lominchar, Jesus V. T. and Bork-Jensen, Jette and Marenholz, Ingo and Arnau-Soler, Aleix and Jeong, Ayoung and Fawcett, Katherine A. and Baurecht, Hansjorg and Rodriguez, Elke and Alves, Alexessander Couto and Kumar, Ashish and Sleiman, Patrick M. and Chang, Xiao and Medina-Gomez, Carolina and Hu, Chen and Xu, Cheng-jian and Qi, Cancan and El-Heis, Sarah and Titcombe, Philip and Antoun, Elie and Fadista, Joao and Wang, Carol A. and Thiering, Elisabeth and Wu, Baojun and Kress, Sara and Kothalawala, Dilini M. and Kadalayil, Latha and Duan, Jiasong and Zhang, Hongmei and Hadebe, Sabelo and Hoffmann, Thomas and Jorgenson, Eric and Choquet, Helene and Risch, Neil and Njolstad, Pal and Andreassen, Ole A. and Johansson, Stefan and Almqvist, Catarina and Gong, Tong and Ullemar, Vilhelmina and Karlsson, Robert and Magnusson, Patrik K. E. and Szwajda, Agnieszka and Burchard, Esteban G. and Thyssen, Jacob P. and Hansen, Torben and Karhus, Line L. and Dantoft, Thomas M. and Jeanrenaud, Alexander C. S. N. and Ghauri, Ahla and Arnold, Andreas and Homuth, Georg and Lau, Susanne and Noethen, Markus M. and Huebner, Norbert and Imboden, Medea and Visconti, Alessia and Falchi, Mario and Bataille, Veronique and Hysi, Pirro and Ballardini, Natalia and Boomsma, Dorret I. and Hottenga, Jouke J. and Mueller-Nurasyid, Martina and Ahluwalia, Tarunveer S. and Stokholm, Jakob and Chawes, Bo and Schoos, Ann-Marie M. and Esplugues, Ana and Bustamante, Mariona and Raby, Benjamin and Arshad, Syed and German, Chris and Esko, Tonu and Milani, Lili A. and Metspalu, Andres and Terao, Chikashi and Abuabara, Katrina and Loset, Mari and Hveem, Kristian and Jacobsson, Bo and Pino-Yanes, Maria and Strachan, David P. and Grarup, Niels and Linneberg, Allan and Lee, Young-Ae and Probst-Hensch, Nicole and Weidinger, Stephan and Jarvelin, Marjo-Riitta and Melen, Erik and Hakonarson, Hakon and Irvine, Alan D. and Jarvis, Deborah and Nijsten, Tamar and Duijts, Liesbeth and Vonk, Judith M. and Koppelmann, Gerard H. and Godfrey, Keith M. and Barton, Sheila J. and Feenstra, Bjarke and Pennell, Craig E. and Sly, Peter D. and Holt, Patrick G. and Williams, L. Keoki and Bisgaard, Hans and Bonnelykke, Klaus and Curtin, John and Simpson, Angela and Murray, Clare and Schikowski, Tamara and Bunyavanich, Supinda and Weiss, Scott T. and Holloway, John W. and Min, Josine L. and Brown, Sara J. and Standl, Marie and Paternoster, Lavinia (2023) European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation. NATURE COMMUNICATIONS, 14 (1): 6172. ISSN , 2041-1723
Full text not available from this repository. (Request a copy)Abstract
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUSCEPTIBILITY LOCI; GENE-EXPRESSION; GWAS; FILAGGRIN; TRANSCRIPTOME; REGRESSION; CHILDREN; VARIANTS; PATHWAYS; REVEALS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 06:32 |
| Last Modified: | 30 Jan 2024 06:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/61005 |
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