Grassmann, Felix and Ach, Thomas and Brandl, Caroline and Heid, Iris M. and Weber, Bernhard H. F. (2015) What Does Genetics Tell Us About Age-Related Macular Degeneration? In: UNSPECIFIED Annual Review of Vision Science,, 1 . ANNUAL REVIEWS, PALO ALTO, pp. 73-96. ISBN 978-0-8243-5101-4
Full text not available from this repository. (Request a copy)Abstract
Age-related macular degeneration (AMD) is a chronic degenerative disease of the central retina and a major cause of vision impairment and blindness with millions of people affected in the elderly population. In recent years, considerable efforts have been made to understand disease pathology with the long-term goal of designing novel and effective treatment options for this devastating disease. Although striking advances in treating the neovascular stage of late AMD have occurred, no therapy is available for almost half of all AMD patients, specifically those who are affected by the atrophic form of the disease. This review highlights current knowledge on the genetic factors associated with early- and late-stage forms of the disease. It also summarizes the findings regarding the extent to which these factors may play a role in the transition from one disease stage to another, and it emphasizes the need to explore further the underlying mechanisms for both development and progression of this disease as a starting point for designing innovative therapies for it.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | PLURIPOTENT STEM-CELLS; RETINAL-PIGMENT EPITHELIUM; ENDOTHELIAL GROWTH-FACTOR; EARLY CHOROIDAL NEOVASCULARIZATION; FUNDUS AUTOFLUORESCENCE PATTERNS; SUBRETINAL DRUSENOID DEPOSITS; BASAL LINEAR DEPOSIT; COMPLEMENT FACTOR-H; GEOGRAPHIC ATROPHY; BRUCHS MEMBRANE; complex disease; AMD; early AMD; neovascular AMD; geographic atrophy AMD; genome-wide association study; histology; treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Lehrstuhl für Humangenetik Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2020 07:13 |
| Last Modified: | 22 Jul 2020 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6119 |
Actions (login required)
 |
View Item |
