Schuettler, Dominik and Piontek, Guido and Wirth, Markus and Haller, Bernhard and Reiter, Rudolf and Brockhoff, Gero and Pickhard, Anja (2015) Selective inhibition of EGFR downstream signaling reverses the irradiation-enhanced migration of HNSCC cells. AMERICAN JOURNAL OF CANCER RESEARCH, 5 (9). pp. 2660-2672. ISSN 2156-6976,
Full text not available from this repository. (Request a copy)Abstract
Irradiation, which is one of the standard therapies used to treat squamous cell carcinoma of the head and neck (HNSCC), has been linked to enhanced tumor migration in carcinomas. In this study, we demonstrated that irradiation induced the phosphorylation of AKT, p38 MAPK and ERK. The combined activation of these pathways caused inactivation of GSK3 beta kinase, resulting in enhanced tumor cell migration. Here, we describe that the exclusive and specific inhibition of just one of the aforementioned key signaling molecules is sufficient to restore GSK3 beta activity and to reduce radiation-induced migration in HNSCC. These data indicate that pharmacological inhibition of pathways targeting GSK3 beta could decrease radiation-induced cell migration in HNSCC and thus potentially reduce metastasis and locoregional recurrence in patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLYCOGEN-SYNTHASE KINASE-3; PROTEIN-KINASE; E-CADHERIN; COMPLEX INTEGRITY; CARCINOMA-CELLS; BETA-CATENIN; ORAL-CANCER; NECK-CANCER; HEAD; PHOSPHORYLATION; Radiation; migration; GSK3 beta |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jul 2019 05:49 |
| Last Modified: | 26 Jul 2019 05:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6159 |
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