Haimerl, Michael and Jung, E. -M. and Beyer, L. P. and Pregler, B. and Dollinger, M. and Sieron, D. and Niessen, C. and Stroszczynski, C. and Wiggermann, P. (2015) Chronic liver disease: Correlation of CEUS-based microperfusion and indocyanine green clearance. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 61 (2). pp. 195-204. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
PURPOSE: To evaluate whether changes of dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation during chronic liver disease are correlated with the extent of impaired liver function, expressed by the indocyanine green (ICG) clearance. MATERIALS AND METHODS: 19 patients underwent CEUS examinations with previous or consecutive ICG clearance test. The ICG plasma disappearance rate (ICG-PDR) was determined using the noninvasive pulse-densitometric LiMON system. Quantification of peak enhancement (PE), rise time (RT) and the wash-in rate (WiR) was performed in the liver parenchyma (ROIliver) as well as in the portal vein (ROIportal (vein)) using a novel quantification software (VueBox (TM)). To compare quantification parameters, patients were classified in patients representing a healthy population (ICG-PDR > 16, n = 8) and those representing patients with liver disease (ICG-PDR <= 16, n = 11). RESULTS: ROIportal (vein) showed significant differences comparing healthy patients and patients with liver disease for all perfusion parameters: PE and WiR were significantly higher in patients without liver disease (p = 0.048; p = 0.039). RT was significantly lower in healthy population (p = 0.039). Comparing perfusion parameters for ROIliver, PE was significantly higher in patients without liver disease (p = 0.039). There was no significant difference for RT (p = 0.804) and WiR (p = 0.058), respectively. CONCLUSION: Within the framework of this study CEUS derived estimation of microcirculation did not prove to be a reliable estimator of liver function. RT, PE and WiR measured in the portal vein were significant perfusion factors in predicting liver function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTRAST-ENHANCED ULTRASOUND; CHRONIC VIRAL-HEPATITIS; PORTAL-HYPERTENSION; DOPPLER SONOGRAPHY; TRANSIT-TIME; BLOOD-FLOW; CIRRHOSIS; DIAGNOSIS; FIBROSIS; PERFUSION; Chronic liver disease; CEUS; ICG-test; microcirculation; liver function |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jul 2019 10:24 |
| Last Modified: | 26 Jul 2019 10:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6166 |
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