Schroeder, Josef A. (2017) Application of laboratory and digital techniques for visual enhancement during the ultrastructural assessment of cilia. ULTRASTRUCTURAL PATHOLOGY, 41 (6). pp. 399-407. ISSN 0191-3123, 1521-0758
Full text not available from this repository. (Request a copy)Abstract
Routine diagnostic electron microscopy of primary ciliary dyskinesia (PCD) is based on the findings of ultrastructural defects of axonemal components. Assessment of the typical abnormalities can be enhanced by improving the sample preservation status using tannic acid (TA) as additive in the biopsy fixation or processing steps. Another option is the implementation of computer-assisted image analysis tools. Advancements in high-resolution 3D visualization of the axonemal structure have been noted, with great potential for the future diagnosis of inherited cilia disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSMISSION ELECTRON-MICROSCOPY; COMPUTER-ASSISTED ANALYSIS; RIGHT BODY ASYMMETRY; INNER DYNEIN ARMS; KARTAGENERS-SYNDROME; CRYOELECTRON TOMOGRAPHY; DYSKINESIA; DIAGNOSIS; DEFECTS; MUTATIONS; Cilia; computer-assisted; diagnostic; image analysis; tannic acid |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 20 Feb 2019 14:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/621 |
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