Albert, Nathalie L. and Nelwan, Debie V. and Fleischmann, Daniel F. and Quach, Stefanie and von Rohr, Katharina and Kaiser, Lena and Teske, Nico and Unterrainer, Lena M. and Bartos, Laura M. and Ruf, Viktoria C. and Brendel, Matthias and Riemenschneider, Markus J. and Wetzel, Christian and Herms, Jochen and Rupprecht, Rainer and Thon, Niklas and Tonn, Joerg-Christian and Belka, Claus and Bartenstein, Peter and von Baumgarten, Louisa and Niyazi, Maximilian and Unterrainer, Marcus and Holzgreve, Adrien (2023) Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH-Wild-Type Glioblastoma. JOURNAL OF NUCLEAR MEDICINE, 64 (10). pp. 1519-1525. ISSN 0161-5505, 1535-5667
Full text not available from this repository. (Request a copy)Abstract
The 18-kDa translocator protein (TSPO) is gaining recognition as a relevant target in glioblastoma imaging. However, data on the potential prognostic value of TSPO PET imaging in glioblastoma are lacking. Therefore, we investigated the association of TSPO PET imaging results with survival outcome in a homogeneous cohort of glioblastoma patients. Methods: Patients were included who had newly diagnosed, histologically confirmed isocitrate dehydrogenase (IDH)-wild-type glioblastoma with available TSPO PET before either normofractionated radiotherapy combined with temozolomide or hypofractionated radiotherapy. SUVmax on TSPO PET, TSPO binding affinity status, tumor volumes on MRI, and further clinical data, such as O (6)-alkylguanine DNA methyltransferase (MGMT) and telomerase reverse transcriptase (TERT) gene promoter mutation status, were correlated with patient survival. Results: Forty-five patients (median age, 63.3 y) were included. Median SUVmax was 2.2 (range, 1.0-4.7). A TSPO PET signal was associated with survival: High uptake intensity (SUVmax > 2.2) was related to significantly shorter overall survival (OS; 8.3 vs. 17.8 mo, P = 0.037). Besides SUVmax, prognostic factors for OS were age (P = 0.046), MGMT promoter methylation status (P = 0.032), and T2-weighted MRI volume (P = 0.031). In the multivariate survival analysis, SUVmax in TSPO PET remained an independent prognostic factor for OS (P = 0.023), with a hazard ratio of 2.212 (95% CI, 1.115-4.386) for death in cases with a high TSPO PET signal (SUVmax > 2.2). Conclusion: A high TSPO PET signal before radiotherapy is associated with significantly shorter survival in patients with newly diagnosed IDH-wild-type glioblastoma. TSPO PET seems to add prognostic insights beyond established clinical parameters and might serve as an informative tool as clinicians make survival predictions for patients with glioblastoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TEMOZOLOMIDE; prognostication; survival; glioma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2024 12:34 |
| Last Modified: | 22 Apr 2024 12:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/62444 |
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