Alves Antunes, Livia Azeredo and Fialho, Walter and Fernandes, Thais de Oliveira and Duarte, Camila and Tavares, Jhenyfer da Silva and Kuchler, Erika Calvano and Antunes, Leonardo Santos (2023) Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries. BRAZILIAN ORAL RESEARCH, 37: e076. ISSN 1807-3107,
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This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms: MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p= 0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMPACT; MTHFR; POLYMORPHISMS; DEPRESSION; VITAMIN-B-12; HOMOCYSTEINE; DISPOSITION; MECHANISMS; ANXIETY; BURDEN; Genetics; Dental caries; Oral health; Quality of life; children |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2024 12:52 |
| Last Modified: | 22 Apr 2024 12:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/62512 |
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