Milenkovic, Vladimir M. and Rupprecht, Rainer and Wetzel, Christian H. (2015) The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 15 (5). pp. 366-372. ISSN 1389-5575, 1875-5607
Full text not available from this repository. (Request a copy)Abstract
The translocator protein 18 kDa (TSPO) is localized in the outer mitochondrial membrane of many cell types and its expression is found to be up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions, and neurological diseases, e.g. amyotrophic lateral sclerosis (ALS). Its primary function is to mediate the transport of cholesterol into the inner compartments of mitochondria. Moreover, TSPO is interacting and building up functional complexes with other mitochondrial proteins such as the voltage-dependent anion channel (VDAC), the adenine nucleotide transporter (ANT), hexokinase I and II and Glycogen synthase kinase 3 beta (GSK3 beta). This mini review will focus on the role of TSPO as a central regulator of mitochondrial function with regard to pathologic states and as a target for new therapeutic strategies for the treatment of psychiatric disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIPHERAL BENZODIAZEPINE-RECEPTOR; DIAZEPAM-BINDING INHIBITOR; ADULT SEPARATION ANXIETY; POSITRON-EMISSION-TOMOGRAPHY; CENTRAL-NERVOUS-SYSTEM; MICROGLIAL ACTIVATION; CHOLESTEROL-BINDING; STEROID-BIOSYNTHESIS; SPECIES-DIFFERENCES; THERAPEUTIC TARGET; Cholesterol; TSPO; mitochondria; XBD-173; PK11195 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Aug 2020 15:29 |
| Last Modified: | 13 Aug 2020 15:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6256 |
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