Von Kobyletzki, Laura and Svensson, Ake and Apfelbacher, Christian and Schmitt, Jochen (2015) Factors That Predict Remission of Infant Atopic Dermatitis: A Systematic Review. ACTA DERMATO-VENEREOLOGICA, 95 (4). pp. 389-394. ISSN 0001-5555, 1651-2057
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The individual prognosis of infants with atopic dermatitis (AD) is important for parents, healthcare professionals, and society. The aim of this study was to investigate predictors for remission of infant AD until school age. A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6-7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. From 3,316 abstracts identified, 2 studies of good study quality were included. Parental allergies and sex did not significantly affect remission. For non-remission of AD, the included articles reported an association with any atopic sensitization at 2 years old (adjusted odds ratio [aOR] 2.76; 95% confidence interval (CI) 1.29-5.91), frequent scratching with early AD (aOR 5.86; 95% CI 3.04-11.29), objective severity score at 2 years old (aOR 1.10; 95% CI 1.07-1.14), and exposure to pets (cat OR 2.33; 95% CI 0.85-6.38). It is largely unknown which factors predict remission of infant AD. This is a highly relevant research gap that hinders patient information on the prognosis of infantonset AD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; BIRTH COHORT; RISK-FACTORS; FOLLOW-UP; ECZEMA; ASTHMA; DISEASE; AGE; ASSOCIATION; MUTATIONS; atopic dermatitis; children; remission; longitudinal study; systematic review; epidemiology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Medical Sociology |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Aug 2020 15:28 |
| Last Modified: | 13 Aug 2020 15:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6257 |
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