de Hesselle, Marie Louise and Borgmann, Stefan and Rieg, Siegbert and Vehreschild, Joerg Janne and Rasch, Sebastian and Koll, Carolin E. M. and Hower, Martin and Stecher, Melanie and Ebert, Daniel and Hanses, Frank and Schumann, Julia (2023) Age and Comorbidity Burden of Patients Critically Ill with COVID-19 Affect Both Access to and Outcome of Ventilation Therapy in Intensive Care Units. JOURNAL OF CLINICAL MEDICINE, 12 (7): 2469. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
During the COVID-19 pandemic, large numbers of elderly, multimorbid people required treatment in intensive care units. This study investigated how the inherent patient factors age and comorbidity burden affected the treatment strategy and the outcome achieved. Retrospective analysis of data from intensive care patients enrolled in the Lean European Open Survey on SARS-CoV2-Infected Patients (LEOSS) cohort found that a patient's age and comorbidity burden in fact influenced their mortality rate and the use of ventilation therapy. Evidence showed that advanced age and multimorbidity were associated with the restrictive use of invasive ventilation therapies, particularly ECMO. Geriatric patients with a high comorbidity burden were clustered in the sub-cohort of non-ventilated ICU patients characterized by a high mortality rate. The risk of death generally increased with older age and accumulating comorbidity burden. Here, the more aggressive an applied procedure, the younger the age in which a majority of patients died. Clearly, geriatric, multimorbid COVID-19 patients benefit less from invasive ventilation therapies. This implies the need for a holistic approach to therapy decisions, taking into account the patient's wishes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTRACORPOREAL MEMBRANE-OXYGENATION; MORTALITY; FRAILTY; COVID-19; SARS-CoV-2; age; comorbidities; intensive care medicine; ventilation; ECMO; mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2024 13:12 |
| Last Modified: | 22 Apr 2024 13:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/62673 |
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