Bein, T. and Mueller, T. and Graf, B. M. and Philipp, A. and Zeman, F. and Schultz, M. J. and Slutsky, A. S. and Weber-Carstens, S. (2015) Factors of tidal volume variation during augmented spontaneous ventilation in patients on extracorporeal carbon dioxide removal. A multivariate analysis. MINERVA ANESTESIOLOGICA, 81 (1). pp. 28-32. ISSN 0375-9393, 1827-1596
Full text not available from this repository. (Request a copy)Abstract
Background. Extracorporeal carbon dioxide removal (ECCO2-R) allows lung protective ventilation using lower tidal volumes (V-T) in patients with acute respiratory failure. The dynamics of spontaneous ventilation under ECCO2-R has not been described previously. This retrospective multivariable analysis examines V-T patterns and investigates the factors that influence V-T, in particular sweep gas flow and blood flow through the artificial membrane. Methods. We assessed V-T, respiratory rate (RR), minute ventilation (MV), and levels of pressure support (0-24 cm H2O), sweep gas flow (0-14 L/min) and blood flow through the membrane (0.8-1.8 L/min) in 40 patients from the moment they were allowed to breathe spontaneously. Modest hypercapnia was accepted. Results. Patients tolerated moderate hypercapnia well. In a generalized linear model the increase in sweep gas flow (P<0.001), a low PaCO2 (P=0.029), and an increased breathing frequency (P<0.001) were associated with lower V-T. Neither blood flow through the membrane (P=0.351) nor the level of pressure support (P=0.595) influenced V-T size. Conclusion. Higher sweep gas flow is associated with low V-T in patients on extracorporeal lung assist and augmented spontaneous ventilation. Such a technique can be used for prolonged lung protective ventilation even in the patient's recovery period.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERVENTIONAL LUNG ASSIST; MECHANICAL VENTILATION; RESPIRATORY-FAILURE; Ventilation; Tidal volume; Respiratory rate |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Aug 2019 11:52 |
| Last Modified: | 01 Aug 2019 11:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/6284 |
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