Schaefer, Hannah and Mayr, Sarah and Buettner-Herold, Maike and Knorr, Karina and Steinhelfer, Lisa and Boeger, Carsten A. and Gschwend, Juergen E. and Heemann, Uwe and Eiber, Matthias and Schmaderer, Christoph and Tauber, Robert (2023) Extensive 177Lu-PSMA Radioligand Therapy Can Lead to Radiation Nephropathy with a Renal Thrombotic Microangiopathy-like Picture. EUROPEAN UROLOGY, 83 (5). pp. 385-390. ISSN 0302-2838, 1873-7560
Full text not available from this repository. (Request a copy)Abstract
Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA) radioligand ther-apy is an option that is increasingly being used for treatment of metastatic castration-resistant prostate cancer. This delivers b-radiation to cells expressing PSMA and high accumulation of the radiopharmaceutical occurs in the kidneys. Here we report three cases of radiation nephropathy with severe chronic kidney disease induced by renal thrombotic microangiopathy following extensive treat-ment with 177Lu-PSMA radioligand therapy. (c) 2022 European Association of Urology. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LU-177-DOTATATE; DOSIMETRY; TOXICITY; IMPACT; Lu-177-PSMA; Metastatic castration -resistant; prostate cancer; Prostate cancer; Radiation nephropathy; Radioligand therapy; Renal toxicity; Theranostics; Chronic kidney disease; Tubulotoxicity; Thrombotic microangiopathy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2024 13:20 |
| Last Modified: | 22 Apr 2024 13:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/62852 |
Actions (login required)
 |
View Item |
