Combining Electrochemical Sensors with Miniaturized Sample Preparation for Rapid Detection in Clinical Samples

Bunyakul, Natinan and Baeumner, Antje J. (2015) Combining Electrochemical Sensors with Miniaturized Sample Preparation for Rapid Detection in Clinical Samples. SENSORS, 15 (1). pp. 547-564. ISSN 1424-8220

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Abstract

Clinical analyses benefit world-wide from rapid and reliable diagnostics tests. New tests are sought with greatest demand not only for new analytes, but also to reduce costs, complexity and lengthy analysis times of current techniques. Among the myriad of possibilities available today to develop new test systems, amperometric biosensors are prominent players best represented by the ubiquitous amperometric-based glucose sensors. Electrochemical approaches in general require little and often enough only simple hardware components, are rugged and yet provide low limits of detection. They thus offer many of the desirable attributes for point-of-care/point-of-need tests. This review focuses on investigating the important integration of sample preparation with (primarily electrochemical) biosensors. Sample clean up requirements, miniaturized sample preparation strategies, and their potential integration with sensors will be discussed, focusing on clinical sample analyses.

Item Type: Article
Uncontrolled Keywords: AMPEROMETRIC GLUCOSE SENSOR; ON-A-CHIP; HUMAN SERUM SAMPLES; WHOLE-BLOOD; URIC-ACID; MICROFLUIDIC DEVICE; PARTICLE SEPARATION; FLOW FRACTIONATION; BIOLOGICAL-FLUIDS; CARBON NANOTUBES; electrochemical sensor; microfluidic-based sample preparation; clinical sample analysis
Subjects: 500 Science > 540 Chemistry & allied sciences
Divisions: Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis)
Depositing User: Petra Gürster
Date Deposited: 13 Aug 2020 15:23
Last Modified: 13 Aug 2020 15:23
URI: https://pred.uni-regensburg.de/id/eprint/6307

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