Maurer, Julia and Kuenzel, Julian and Bohr, Christopher and Koelbl, Oliver and Mueller, Karolina and Koller, Michael and Concato, Oreste-Konrad and Vielsmeier, Veronika and Suess, Christoph (2024) Laryngectomy plus postoperative radio(system)therapy versus primary radio(system) therapy for the treatment of locally advanced laryngeal and hypopharyngeal cancer - results from the University Clinical Cancer Registry Regensburg. ACTA OTO-LARYNGOLOGICA, 144 (3). pp. 255-262. ISSN 0001-6489, 1651-2251
Full text not available from this repository. (Request a copy)Abstract
Background: There are few adequate randomized clinical trials directly comparing the therapeutic options of primary laryngectomy (pLE) vs. primary radio(system)therapy (pR(S)T) in patients with locally advanced laryngeal and hypopharyngeal carcinoma and thus little clear scientific evidence to decide which patients will benefit most from which procedure. Aims/Objectives Aim was to compare survival between the therapeutic options and to learn from the limitations of this study, especially in the context of improved clinical assessment. Material and Methods: The clinical data of patients treated between January 2010 and February 2022 were obtained from the electronic database of the University Hospital Regensburg. Overall survival (OS) and progression-free survival (PFS) were compared between the treatment groups. Results: The study included 193 patients (pLE n = 68, pR(S)T, n = 125). Median OS was 31.2 months and median PFS was 24.7 months with no significant difference between the treatment groups (p > .050). Patients who did not receive complete treatment as recommended by the tumor conference (n = 47, 24.4%) had a higher risk of death (p = .024). Conclusions and Significance: The results of our study are consistent with the survival data reported in the literature. More detailed systematic data in clinical routine (e.g. relevant comorbidities) are required to ensure guideline-based recommended therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORGAN-PRESERVATION; RADIATION-THERAPY; OUTCOMES; CHEMOTHERAPY; RADIOTHERAPY; STRATEGIES; MANAGEMENT; SURVIVAL; HEAD; Hypopharygeal/laryngeal cancer; laryngectomy; primary radio(system)therapy; overall survival; recommended therapy |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 06:11 |
| Last Modified: | 15 Jul 2025 06:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63349 |
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