Kieninger, B. and Fechter, R. and Baeumler, W. and Raab, D. and Rath, A. and Caplunik-Pratsch, A. and Schmid, S. and Mueller, T. and Schneider-Brachert, W. and Eichner, A. (2024) Photodynamic coatings kill bacteria on near-patient surfaces in intensive care units with low light intensities. JOURNAL OF HOSPITAL INFECTION, 153. pp. 39-46. ISSN 0195-6701, 1532-2939
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Background: Surfaces in close proximity to patients within hospitals may cause healthcare-associated infections. These surfaces are repositories for pathogens facilitating their transmission among staff and patients. Regular cleaning and disinfection of these surfaces provides only a temporary elimination of pathogens with inevitable recontamination. Antimicrobial coatings (AMCs) of such surfaces may additionally reduce the risk of pathogen transmissions. Aim: To evaluate the efficacy of a standard and a novel photodynamic AMC, even at very low light intensities, in a field study conducted in two ICUs at our university hospital. Methods: The microbial burden was determined on three coatings: standard photodynamic AMC (A), a novel photodynamic AMC (B), and an inactive AMC as control (C). The control coating C was identical to standard coating A, but it contained no photosensitizer. During a three-month period, 699 samples were collected from identical surfaces using eSwab and were analysed (cfu/cm2). Findings: Mean values of all surfaces covered with control coating (C) showed a microbial burden of 5.5 + 14.8 cfu/cm2. Photodynamic AMC showed significantly lower mean value of 1.6 + 4.6 cfu/cm2 (coating A; P < 0.001) and 2.7 + 9.6 (coating B; P < 0.001). When considering a benchmark of 2.5 cfu/cm2, the relative risk for higher microbial counts was reduced by 52% (coating A) or 40% (coating B), respectively. Conclusion: Both photodynamic AMCs offer a substantial, permanent risk reduction of microbial counts on near-patient surfaces in ICUs with low light intensities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIDRUG-RESISTANT BACTERIA; ENVIRONMENTAL SURFACES; Antimicrobial surface; Photodynamic coating; Decontamination; Pathogen transmission; Hospital-acquired infections |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 08:50 |
| Last Modified: | 15 Jul 2025 08:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63361 |
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