Araceli, Tommaso and Fischl, Anna and Haj, Amer and Doenitz, Christian and Stoerr, Eva-Maria and Hillberg, Andrea and Vogelhuber, Martin and Rosengarth, Katharina and Riemenschneider, Markus J. and Hau, Peter and Blazquez, Raquel and Pukrop, Tobias and Bumes, Elisabeth and Schmidt, Nils Ole and Proescholdt, Martin (2024) Psycho-oncological burden in patients with brain metastases undergoing neurological surgery. FRONTIERS IN ONCOLOGY, 14: 1463467. ISSN 2234-943X,
Full text not available from this repository. (Request a copy)Abstract
Purpose The development of brain metastases (BM) can significantly increase the psycho-oncological burden in cancer patients, requiring timely intervention. In addition, this aspect may negatively affect the course of the disease and treatment outcome. However, screening for psycho-oncological burden is often overlooked in clinical routine. Therefore, we analyzed the extent of psycho-oncological distress in a patient population with BM receiving neurosurgical resection and identified clinical characteristics associated with a high need for psycho-oncological intervention.Methods We prospectively screened 353 patients (169 female, 184 male, mean age 61.9 years) scheduled for microsurgical resection of one or more BM. Psycho-oncological screening was performed on the day of admission using the Hornheider screening instrument (HSI) and the distress thermometer (DT). Screening results were correlated with demographic and clinical data.Results Most patients (73.1%) completed the screening questionnaire. Patients who failed to complete the questionnaire presented more frequently with metachronous BM (74.7% vs. 25.3%, p=0.009), were significantly older (p=0.0018), and had a significantly lower KPS score (p=0.0002). Based on the threshold values of the questionnaires, 59.3% of the patients showed a significant psycho-oncological burden requiring immediate intervention. Univariate analysis demonstrated that synchronous BM (p=0.034), tumors in eloquent areas (p=0.001), lower KPS (p=0.031), female gender (p=0.009), and presurgical aphasia (p=0.042) were significantly associated with high psycho-oncological burden. Multivariate analysis showed synchronous BM (p=0.045), female gender (p=0.005), and lower KPS (p=0.028) as independent factors associated with high psycho-oncological burden.Conclusion The majority of patients with BM have a high psycho-oncological burden. Female gender, synchronous BM, and lower KPS are independently associated with a need for psycho-oncological intervention.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; SUPPORTIVE CARE NEEDS; PSYCHOLOGICAL DISTRESS; CANCER-PATIENTS; TUMOR PATIENTS; GENDER; PREVALENCE; DEPRESSION; QUESTIONNAIRE; THERMOMETER; psycho-oncology; brain tumor; neurosurgery; psychological distress; psycho-oncological need |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 06:36 |
| Last Modified: | 15 Jul 2025 06:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63376 |
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