Fischl, Anna and Gerken, Michael and Lindberg-Scharf, Patricia and Haedenkamp, Tareq M. and Rosengarth, Katharina and Hillberg, Andrea and Vogelhuber, Martin and Schoen, Ingrid and Proescholdt, Martin and Araceli, Tommaso and Koeller, Michael and Herrmann, Anne and Koelbl, Oliver and Pukrop, Tobias and Riemenschneider, Markus J. and Schmidt, Nils Ole and Klinkhammer-Schalke, Monika and Linker, Ralf and Hau, Peter and Bumes, Elisabeth (2024) Health-Related Quality of Life and Treatment Satisfaction of Patients with Malignant IDH Wild-Type Gliomas and Their Caregivers. CURRENT ONCOLOGY, 31 (10). pp. 6155-6170. ISSN 1198-0052, 1718-7729
Full text not available from this repository. (Request a copy)Abstract
(1) Background: Clinical aspects like sex, age, Karnofsky Performance Scale (KPS) and psychosocial distress can affect the health-related quality of life (HR-QoL) and treatment satisfaction of patients with malignant isocitrate dehydrogenase wild-type (IDHwt) gliomas and caregivers. (2) Methods: We prospectively investigated the HR-QoL and patient/caregiver treatment satisfaction in a cross-sectional study with univariable and multiple regression analyses. Questionnaires were applied to investigate the HR-QoL (EORTC QLQ-C30, QLQ-BN20) and treatment satisfaction (EORTC PATSAT-C33). (3) Results: A cohort of 61 patients was investigated. A higher KPS was significantly associated with a better HR-QoL regarding the functional scales of the EORTC QLQ-C30 (p < 0.004) and a lower symptom burden regarding the EORTC QLQ-BN20 (p < 0.001). The patient treatment satisfaction was significantly poorer in the patients older than 60 years in the domain of family involvement (p = 0.010). None of the investigated aspects showed a significant impact on the treatment satisfaction of caregivers. (4) Conclusions: We demonstrated that in patients with IDHwt gliomas, the KPS was the most important predictor for a better HR-QoL in functional domains. Data on the HR-QoL and treatment satisfaction in patients with IDHwt gliomas and their caregivers are rare; therefore, further efforts should be made to improve supportive care in this highly distressed cohort.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REPORTED OUTCOME MEASURES; CENTRAL-NERVOUS-SYSTEM; RESPONSE ASSESSMENT; BRAIN-TUMOR; CANCER; SYMPTOMS; CARE; SEX; glioma; IDH wild-type; psycho-oncology; health-related quality of life; HR-QoL; satisfaction |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 13:50 |
| Last Modified: | 15 Jul 2025 13:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/63385 |
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